MEETING ON CELL DEATH AND CANCER

请求支持美国政府组织的一次科学会议 癌症研究协会(AACR)。会议的题目是， “细胞死亡与癌症”将在查塔姆的查塔姆酒吧酒店举行， 马萨诸塞州，1993年10月17日至21日。这方面的项目委员会 会议由主席兼校长艾伦·R·伊斯曼博士组成 调查员：Nathan Berger，H.Robert Horvitz，John Isaacs，Stanley 书名/作者声明：[by]A.除 节目委员会的成员，受邀的演讲者是众所周知的， 这一领域的杰出调查人员。演讲者将使30-60- 会议纪要。约150-175名其他会议注册人 将有机会在海报期间展示自己的小说作品 会话。 对癌症的许多分子理解都源于 癌基因和抑癌基因的鉴定和分析 它们的异常表达会导致细胞生长增加。它已经变成了 在过去的几年里，越来越明显的是，肿瘤不仅仅是 这是细胞生长速度的反映，也是细胞死亡速度的反映。 Bcl2癌基因的观察突显了这一点 防止了细胞死亡。防止细胞死亡的类型被称为 细胞凋亡，这是由形态定义的，由一种特有的模式 DNA的消化和蛋白质合成的明显需求。 其他也可以防止细胞凋亡的基因正在被发现。 这为理解这一过程提供了巨大的推动力 细胞凋亡；1972年首次发现的一种途径，但已收到 在这些最近的发现之前，人们对此并不感兴趣。 这次会议旨在首次将个人聚集在一起 从不同的研究领域，让他们受益于 对细胞凋亡的许多方面进行全面而深入的分析。它 将建立在这样一个前提之上，即细胞凋亡是一种公认的 现象，因此将主要集中在基因、蛋白质信号上 调节这些通路，并讨论它可能如何被 对治疗有很强的促进作用。这将是有史以来的第一次会议 致力于细胞凋亡的主题，并向所有人开放 调查人员。以前的会议都是应邀举行的，或者 只有一次会议专门讨论了这一主题。

Support is requested for a scientific meeting organized by the American Association for Cancer Research, Inc. (AACR). The conference entitled, "Cell Death and Cancer," will be held at the Chatham Bars Inn in Chatham, Massachusetts, on October 17-21, 1993. The Program Committee for this conference consists of Drs. Alan R. Eastman, Chairperson and Principal Investigator; Nathan Berger, H. Robert Horvitz, John Isaacs, Stanley Korsmeyer, Thomas R. Tritton, and Andrew Wyllie. In addition to the members of the Program Committee, the invited speakers are well-known, distinguished investigators in this field. Speakers will make 30- to 60- minute presentations. Approximately 150-175 other conference registrants will have the opportunity to present their own novel work during poster sessions. Much of the molecular understanding of cancer has arisen from identification and analysis of oncogenes and tumor suppressor genes, the aberrant expression of which lead to increased cell growth. It has become increasingly evident over the past several years, that tumors are not just a reflection of the rate of cell growth but also the rate of cell death. This position was highlighted by the observation that bcl-2 oncogenes prevented cells from dying. The type of cell death prevented is known as apoptosis, which is defined by morphology, by a characteristic pattern of DNA digestion and by the apparent requirement for protein synthesis. Other genes are now being identified that can also prevent apoptosis. This has provided a tremendous impetus to understand the process of apoptosis; a pathway first identified in 1972, but which has received little general interest until these recent findings. This meeting is designed to bring together for the first time individuals from diverse areas of research, and to let them benefit from a comprehensive, yet in depth analysis of the many facets of apoptosis. It will build upon the premise that apoptosis is a well established phenomenon, and will therefore focus mainly on the genes, proteins signals that regulate the pathways, and discuss how it might be modulated with potent for therapeutic gain. This will be the first ever meeting dedicated to the subject of apoptosis and that is open to all investigators. Previous meetings have been by invitation only or have devoted only a single session to this topic.