CHROMATIN AND TRANSCRIPTION--FASEB SUMMER RESEARCH CONF.

在过去的十年中，一项相当大的研究工作具有以下特点 大量的转录因子，并剖析了其调控元件 很多基因。尽管取得了这种成功，但我们对这些问题知之甚少 因子和元素在核内发挥作用。DNA的致密化 进入染色质和染色体带来了许多问题，但潜在地 提供了许多关于转录调控的见解。方法论 突破性进展正在导致在理解如何 细胞核结构和染色质结构是在体内形成的。这些 结果表明，因子、DNA和结构蛋白相互作用 促进基因的调控。拟议中的会议的目的 是批判性地分析我们目前对核能如何 组织对基因调控做出贡献，并解决最 为进一步调查提供了卓有成效的途径。通过将 领先的分子遗传学家、分子生物学家、生物化学家和 生物物理学家在这个快速发展的领域中，概念和 特别成功的方法论方法可能是 在密集和非正式的环境中进行了严格的讨论。一位少校 这样一个会议的目的是作为一种催化剂，刺激 可能已经拥有工具的科学家的广泛受众的兴趣 在探讨核结构背景下的基因调控时， 重点关注那些尚未发起 独立研究的主要领域。

A considerable research effort in the past decade has characterized numerous transcription factors and dissected the regulatory elements of many genes. In spite of this success we know little concerning how these factors and elements function within the nucleus. The compaction of DNA into chromatin and chromosomes poses many problems, and yet potentially provides many insights into transcriptional regulation. Methodological breakthroughs are leading to substantial progress in understanding how nuclear architecture and chromatin structure is shaped in vivo. These results suggest that factors, DNA and structural proteins interact to facilitate the regulation of genes. The purpose of the proposed meeting is to critically analyze our current understanding of how nuclear organization contributes to gene regulation and to address the most fruitful avenues for further investigation. By bringing together the leading molecular geneticists, molecular biologists, biochemists and biophysicists in this rapidly developing field, the concepts and methodological approaches that are particularly successful can be rigorously discussed in an intensive and informal environment. A Major aim of such a conference is to serve as a catalyst for stimulating the interest of a wide audience of scientists who may already have the tools in hand to approach gene regulation in the context of nuclear structure, with a focus upon those young investigators who are yet to initiate a major area of independent research.