ION-MOTIVE ATPASE OF THE CARDIOVASCULAR SYSTEM

这项申请的目的是获得资金，以部分支持 一些与会者参加一个名为 “离子动力ATPase：结构、功能与调控”将在北京举行 1992年夏天，俄亥俄州克利夫兰。 这次会议将由纽约协会赞助 中科院将为46位演讲者提供机会，80张海报 演讲者和150名参与者将会面四天，并交流 关于结构、功能和功能各方面的最新信息 对各种ATPase的调节。会议的形式包括 上午的站台演示文稿和海报演示文稿 下午的餐桌讨论。待讨论的ATPase列表 广泛分布，包括钙离子、Na+-K+、H+-K+、H+和Mg2+转运的ATPase。 这些将关于一级结构和二级结构进行讨论， 催化部位，同工酶，动态结构，调节，亚基的作用， 基因操纵等。 四个跨学科圆桌会议将集中讨论：进化 荷尔蒙和代谢调节的结构同源性；药物设计 用于ATPase；以及构造函数关系。 这次会议将有大量的国际代表和健康的 既有成熟的调查人员，也有年轻的调查人员。会议将于 广泛刊登广告，并发表会议记录和讨论 适时地以均匀分布的卷。

The purpose of this application is to obtain funding for partial support of travel and lodging for some participants to a conference entitled "Ion-Motive ATPases: Structure, Function and Regulation" to be held in Cleveland, OH in the summer of 1992. The conference which will be held under the sponsorship of the New York Academy of Science will provide the opportunity for 46 speakers, 80 poster presenters and 150 participants to meet for four days and to exchange the latest information on the various aspect of structure, function and regulation of various ATPases. The format of the conference consists of platform presentations in the morning and poster presentations and round table discussions in the afternoons. The list of ATPases to be discussed is broad and includes Ca2+, Na+-K+, H+-K+,H+ and mg2+ transporting ATPases. Those will be discussed with respect to primary and secondary structure, catalytic sites, isozymes, dynamic structure, regulation, role of subunits, genetic manipulation, etc. Four interdisciplinary round tables will focus the discussion on: evolution and structural homologies of hormonal and metabolic regulation; drug design for ATPases; and structure function relationships. The conference will have a large international representation and a healthy mix of established and young investigators. The conference will be advertised extensively and the proceeding and the discussion published timely in a well distributed volume.