SELECTIVE PHOTOCOAGULATION OF CHOROIDAL VESSELS

我们的目标是开发一个理论和实验模型，以选择 脉络膜血管的凝结。尽管激光占据着重要的角色 在眼科疾病的治疗中，眼科激光的发展 在很大程度上是经验性的，因为激光的可用性 信号源决定了哪些波长、脉宽和能量 学习。激光在眼科的未来应用进展 很可能依赖于激光和技术的发展来限制 激光对特定组织或超微结构目标的影响。我们建议 (1)在开发和实验方面扩大我们的初步研究 评价一种策略(选择性光热分解)以优化选择性 关闭脉络膜和视网膜血管，同时最大限度地减少对 神经视网膜；(2)使用理论模型预测哪些波长， 脉冲持续时间和入射曝光能量密度可以最好地实现 以必要的速率进行现场选择性加热；(3)有选择地有针对性地使用 染料使近红外选择性光热分解成为可能 地区，在首先对技术进行建模以选择最佳可用的 染料和波长。这种方法具有很大的潜在价值，因为 染料靶向选择性光热分解在避免 对视网膜色素上皮和神经的直接影响 视网膜可用于各种程序，潜在地减少损害 神经视网膜；(4)在动物模型上进行一系列研究 旨在将连续的临床、组织学和超微结构联系起来 基于物理模型的理论预测对激光曝光的响应 模特和治疗目标。紫翠宝石、铒和可调谐染料 激光将在这些研究中使用。

We aim to develop a theoretical and experimental model for selective coagulation of choroidal vessels. Although lasers occupy an important role in the treatment of ocular disease, the development of ophthalmic lasers has been, in large measure, empirical because the availabililty of laser sources determined which wavelengths, pulsewidths, and energies were studied. The development of future applications of lasers in ophthalmology is likely to rely on the development of lasers and techniques to confine laser effects to specific tissue or ultrastructural targets. We propose to (1) extend our preliminary studies in developing and experimentally evaluating a strategy (selective photothermolysis) for optimizing selective closure of choroidal and retinal vessels while minimizing damage to the neural retina; (2) use theoretical models to predict which wavelengths, pulse durations and incident exposure energy densities can best achieve site selective heating at the rates necessary; (3) use selectively targeted dyes to make selective photothermolysis possible in the near infrared region, after first modelling the technique to select the best available dyes and wavelengths. This approach is of great potential value because dye-targeted selective photothermolysis at wavelengths which avoid significant direct effects upon the retinal pigment epithelium and neural retina may be used for a variety of procedures, potentially reducing damage to the neural retina; (4) perform in animal models a series of studies designed to correlate sequential clinical, histological and ultrastructural responses to laser exposures with theoretical predictions based on physical models and with therapeutic goals. Alexandrite, erbium and tunable dye lasers will be used in these studies.