课题基金 / 基金详情

MYOCARDIAL CALCIUM LOCALIZATION BY X-RAY MICROANALYSIS

MYOCARDIAL CALCIUM LOCALIZATION BY X-RAY MICROANALYSIS
通过 X 射线微分析进行心肌钙定位
批准号:
3448605
负责人:
MARIE E CANTINO
金额:
$4.7万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-01-01 至 1986-12-31

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中文摘要
翻译
建议项目的目标是:
英文摘要
The objectives of the proposed project are: 1. To use the technique of Energy Dispersive X-ray Spectroscopy (EDS) to quantify calcium and other biologically important elements in subcellular regions of mammalian myocardium known to bind or sequester calcium (terminal cisternae, mitochondria, I-band). 2. To measure changes in the concentrations of calcium and other elements at these sites under conditions which have been hypothesized to directly affect storage or release of calcium in myocardium. In particular, we will investigate the effects of a) caffeine, b) varying extracellular calcium, and c) varying sarcomere length on resting and tetanized (in the presence of caffeine) ventricular muscle. 3. To adapt a relatively new freezing method (propane jet freezing) for the study of intact myocardial tissue, with the ultimate goal of studying beat-to-beat variations in subcellular elemental distributions.
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ROLES OF MYOFILAMENT BOUND CALCIUM IN MUSCLE CONTRACTION
  • 批准号:
    2028827
  • 项目类别:
  • 资助金额:
    $11.67万
  • 财政年份:
    1995
  • 负责人:
    MARIE E CANTINO
  • 依托单位:
ROLE OF MYOFILAMENT BOUND CALCIUM IN MUSCLE CONTRACTION
  • 批准号:
    6389255
  • 项目类别:
  • 资助金额:
    $17.88万
  • 财政年份:
    1995
  • 负责人:
    MARIE E CANTINO
  • 依托单位:
ROLE OF MYOFILAMENT BOUND CALCIUM IN MUSCLE CONTRACTION
  • 批准号:
    6603423
  • 项目类别:
  • 资助金额:
    $17.88万
  • 财政年份:
    1995
  • 负责人:
    MARIE E CANTINO
  • 依托单位:
ROLE OF MYOFILAMENT BOUND CALCIUM IN MUSCLE CONTRACTION
  • 批准号:
    6191511
  • 项目类别:
  • 资助金额:
    $20.97万
  • 财政年份:
    1995
  • 负责人:
    MARIE E CANTINO
  • 依托单位:
海外基金