TYPE A BEHAVIOR: AN EPIDEMIOLOGIC STUDY OF TWIN FAMILIES

A型行为模式的家族聚集性及其组成部分， 冠心病的标准危险因素（总胆固醇和 甘油三酯、HDL-C和LDL-C、收缩压和舒张压， 相对重量）将进行调查。 本次流行病学调查的样本 这项研究将包括275对双胞胎，6至11岁，他们的 父母 遗传和环境的变异来源将是 通过比较同卵对和同性异卵对来确定。 异性双胞胎将作为配对进行分析， 儿童A型行为模式的差异。 将 确定A型行为模式或其组成部分是否 与任何标准风险因素相关， 人口 将研究这些特征的家族聚集性 利用双胞胎及其父母的数据。 确定A型行为模式在多大程度上 儿童的遗传因素可以归因于遗传因素。 一旦这已经 完成后，将有必要确定具体的环境 与发展这种风险因素的倾向相互作用的因素。 它 预计这项研究的结果将提供深入了解 A型行为模式的起源

Familial aggregation of the Type A behavior pattern, its components and standard risk factors for coronary heart disease (total cholesterol and trigylcerides, HDL-C and LDL-C, systolic and diastolic blood pressure and relative weight) will be investigated. The sample for this epidemiologic study will consist of 275 twin pairs, six to eleven years old, and their parents. Genetic and environmental sources of variation will be ascertained by comparing monozygotic pairs with same-sex dizygotic pairs. Opposite-sex twins will be analyzed as matched pairs to examine sex differences in the Type A behavior pattern among children. It will be determine whether or not the Type A behavior pattern or its components is correlated with any of the standard risk factors in this pediatric population. Familial aggregation of these characteristics will be studied using data on the twins and their parents. It is important to identify the extent to which the Type A behavior pattern in children can be attributed to genetic factors. Once this has been accomplished it will be necessary to determine the specific environmental factors that interact with the propensity to develop this risk factor. It is anticipated that the results of this study will provide insight into the origins of the Type A behavior pattern.