TYPE A BEHAVIOR: AN EPIDEMIOLOGIC STUDY OF TWIN FAMILIES

A型行为模式的家族聚集性及其构成因素 冠心病的标准危险因素(总胆固醇和 甘油三酯，高密度脂蛋白胆固醇和低密度脂蛋白胆固醇，收缩压和舒张压 相对重量)将进行调查。这份流行病学的样本 研究将由275对双胞胎组成，年龄在6岁到11岁之间，他们的 父母。变异的遗传和环境来源将是 通过比较单合子对和同性双合子对来确定。 异性双胞胎将被分析为配对，以检查性别 儿童A型行为模式的差异。会是 确定A型行为模式或其组件是否 与本儿科的任何标准危险因素相关 人口。这些特征的家族聚集性将被研究 利用这对双胞胎及其父母的数据。 重要的是要确定A型行为模式的程度 对儿童的影响可以归因于遗传因素。一旦这件事发生了 完成后，将有必要确定特定环境 与发生这种风险因素的倾向相互作用的因素。它 预计这项研究的结果将提供对 A型行为模式的起源。

Familial aggregation of the Type A behavior pattern, its components and standard risk factors for coronary heart disease (total cholesterol and trigylcerides, HDL-C and LDL-C, systolic and diastolic blood pressure and relative weight) will be investigated. The sample for this epidemiologic study will consist of 275 twin pairs, six to eleven years old, and their parents. Genetic and environmental sources of variation will be ascertained by comparing monozygotic pairs with same-sex dizygotic pairs. Opposite-sex twins will be analyzed as matched pairs to examine sex differences in the Type A behavior pattern among children. It will be determine whether or not the Type A behavior pattern or its components is correlated with any of the standard risk factors in this pediatric population. Familial aggregation of these characteristics will be studied using data on the twins and their parents. It is important to identify the extent to which the Type A behavior pattern in children can be attributed to genetic factors. Once this has been accomplished it will be necessary to determine the specific environmental factors that interact with the propensity to develop this risk factor. It is anticipated that the results of this study will provide insight into the origins of the Type A behavior pattern.