Circuit, cellular and synaptic mechanisms of nucleus accumbens deep brain stimulation

脑深部电刺激具有巨大的潜力，可以帮助那些无法从所有其他治疗中获益的脑功能障碍患者。为了确保实现这一潜力，我们必须了解它是如何工作的。该项目将确定大脑刺激如何改变信息在大脑中调节对消极和积极事件反应的部分中传输的方式。这些信息对于帮助改善脑刺激治疗和患者的临床结果是必要的。

Deep brain stimulation has immense potential to help patients with brain-based disorders that fail to benefit from all other treatments. To ensure this potential is realised, we must understand how it works. This project will determine how brain stimulation changes the way information is transmitted in a part of the brain that regulates responses to negative and positive events. This information is necessary to help improve brain stimulation treatments and clinical outcomes for patients.