Circulating tumour DNA analysis of acquired treatment resistance in breast cancer
Circulating tumour DNA analysis of acquired treatment resistance in breast cancer
批准号:
nhmrc : GNT1085014
负责人:
A/Pr SarahJane Dawson
金额:
$33.06万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
紫杉烷类是乳腺癌常用的化疗药物,但治疗耐药性仍然是一个重要的临床问题,需要新的方法。许多癌症会将少量DNA(循环肿瘤DNA(ctDNA))排入血液,ctDNA的分析可以评估治疗期间发生的肿瘤特异性基因组变化。该项目旨在利用ctDNA研究转移性乳腺癌对紫杉烷类化疗的获得性治疗耐药性。
英文摘要
Taxanes are commonly used chemotherapeutic agents in breast cancer, yet treatment resistance remains a significant clinical problem for which new approaches are needed. Many cancers shed small amounts of DNA (circulating tumor DNA (ctDNA)) into the bloodstream, and analysis of ctDNA can allow assessment of tumour specific genomic changes occurring during treatment. This project aims to utilise ctDNA to study acquired treatment resistance to taxane-based chemotherapy in metastatic breast cancer.
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