NUTRITION AND HYPERTENSION: ROLE OF HYPERINSULINEMIA

虽然肥胖是一种已知的风险因素，但它会导致 高血压，肥胖增加高血压风险的机制 人们对高血压知之甚少。有议员建议， 与肥胖相关的高胰岛素血症/胰岛素抵抗 通过刺激交感神经来促进高血压的发展 神经系统，增加肾脏钠的重吸收，并增加 外周血管阻力。这些系统的改变并没有 在肥胖相关高血压的动物模型中具有特征性。 这个应用程序的长期目标是理解 肥胖引起高血压的机制。的具体目标 这个应用程序是：1.检查和描述关系 犬高胰岛素血症/胰岛素抵抗与血压的关系 以及高血压的啮齿动物模型。2.确定可变胰岛素是否 被认为导致胰岛素依赖的系统的敏感性 高血压解释了肥胖引起的血压变化。 3.研究肾功能、交感神经系统和肾功能的变化 肥胖相关动物模型的局部血管阻力 高血压。4.评估高饱和脂肪与低饱和脂肪的作用 饮食中表现为饮食肥胖和高血压。这些 研究将在整个动物身上完成。肌肉的敏感度 胰岛素刺激的血糖处理，肾脏对胰岛素的刺激 钠重吸收和交感神经系统对胰岛素的作用 刺激将使用高胰岛素钳夹进行评估。肾 功能将通过测量电解质排泄量来评估 受图标控制的条件。SNS活动将通过以下方式进行评估 循环儿茶酚胺。心血管功能与局部 血管阻力将通过放射性微球进行评估 技术。

Although obesity is a known risk factor for the development of hypertension, the mechanisms by which obesity increase the risk for hypertension are poorly understood. It has been proposed that the hyperinsulinemia/insulin resistance associated with obesity contributes to the development of hypertension by stimulating the sympathetic nervous system, increasing renal sodium reabsorption, and increasing peripheral vascular resistance. Alterations in these systems have not been characterized in animal models of obesity-related hypertension. The long-term objective of this application is to understand the mechanisms which produce hypertension in obesity. The specific aims of this application are: 1. To examine and characterize the relationship between hyperinsulinemia/insulin resistance and blood pressure in canine and rodent models of hypertension. 2. To determine if variable insulin sensitivity of the systems which are thought to cause insulin dependent hypertension explains the variable blood pressure response to obesity. 3. To study changes in renal function, sympathetic nervous system and regional vascular resistance in animal models of obesity-associated hypertension. 4. To assess the role of high versus low saturated fat diet in the expression of dietary obesity and hypertension. These studies will be completed in the whole animal. Sensitivity of muscle to insulin stimulated glucose disposal, of kidney to insulin stimulated sodium reabsorption and of the sympathetic nervous system to insulin stimulation will be assessed using a hyperinsulinemic clamp. Renal function will be assessed by measuring electrolyte excretion under icontrolled conditions. SNS activity will be assessed by measuring circulating catecholamines. Cardiovascular function and regional vascular resistance will be ,assessed by the radioactive microsphere technique.