METALLACYCLOBUTENES, SYNTHESIS AND REACTIVITY

新的碳-碳键的构建是 合成的复杂分子经常被发现显示出有用的 或有趣的生化或生理活动。 有机过渡金属络合物继续提供多种新的 形成键的方法。金属环丁烯与 不饱和有机底物，例如羰基化合物， 氰化物和亚硫醚，产生有机金属配合物， 可转化为多种重要的杂环化合物 有机分子。概论与功能群 我们将探讨对这些转换的容忍度。进一步 综合应用将通过合成一种 一系列新的金属环丁烯，其中系统变化 过渡金属和它的支持配体将允许 金属循环反应性的粗调和微调 底物专一性。

The construction of new carbon-carbon bonds is central to the synthesis of the complex molecules often found to display useful or interesting biochemical or physiological activity. Organotransition metal complexes continue to offer versatile new approaches to bond formation. Metallacyclobutenes react with unsaturated organic substrates such as carbonyl compounds, nitriles, and sulfoxides, yielding organometallic complexes which may be transformed into a wide variety of important heterocyclic organic molecules. The generality and functional group tolerances of these transformations will be explored. Further synthetic applications will be achieved through the synthesis of a series of new metallacyclobutenes, in which systematic variation of the transition metal and of its supporting ligands will permit both coarse and fine tuning of metallacycle reactivity and substrate specificity.