Clamp stabilized vaccines to provide broad spectrum protection against influenza

目前流感疫苗提供的疾病防护受到病毒株特异性较窄的限制。我们开发了一种新的“分子钳”技术，将主要的病毒免疫靶标限制在其天然结构中。免疫可导致免疫反应，病毒杀伤能力增强，交叉反应能力增强，对不同病毒的保护能力增强。我们的方法将进一步发展，并与目前的商业疫苗进行比较。

Protection against disease provided by current influenza vaccines is limited by narrow virus strain specificity. We developed a novel ‘molecular clamp’ technology that constrains the major viral immune target into its native structure. Immunization results in immune responses with increased virus killing and improvements in cross-reactivity and protection against divergent viruses. Our approach will be further developed and compared to current commercial vaccines.