FETAL CEREBRAL RESPONSE TO SOUND STIMULATION

这个项目的长期目标是描述胎儿的特征 大脑对声音应用的代谢和行为反应 在生理和病理条件下。虽然声音的刺激 在临床产科社区迅速流行起来 关于胎儿评估的方法，人们对其对胎儿的影响知之甚少 胎儿或胎儿的大脑。最近的数据表明，声音刺激 导致整个大脑中胎儿葡萄糖代谢的显著增加 大脑皮层。此外，对正常供氧成年人的研究表明， 刺激引起的葡萄糖消耗增加是代谢的 无氧运动。因此，对胎儿施加声音可能会导致局部 胎儿大脑产生的乳酸可能对人体有害 胎儿。胎羊将被慢性插管和微球 脑血流量的测量将在有无 声音刺激的应用。动-静脉血糖的差异， 将获得氧气和乳酸，并计算大脑净流量。在……里面 此外，将通过测量心脏来评估行为反应 心率、脑电、四肢和颈项肌电。这个 大脑反应的发展将从以下方面进行调查 胎龄。胎儿对刺激的习惯性将是其特征 并将探索习惯化的新陈代谢后果。胎儿 对声音的反应将在缺血期间和之后确定，这段时间是 已经观察到行为反应和代谢反应之间的分离。 在成人身上。目标是一个。)建立一个知识基础， 大脑对声音的代谢和行为反应，以便更充分地 评估使用声音作为一种工具的临床实用性和安全性 诊断胎儿健康和b.)以声音刺激为模型 以确定无氧代谢的贡献 生理和病理过程中的总葡萄糖消耗 作为刺激的结果的情况。

The long-term objectives of this project are to characterize the fetal cerebral metabolic and behavioral response to the application of sound during physiologic and pathologic conditions. Although stimulation by sound is rapidly gaining popularity in the clinical obstetric community as a means of fetal assessment, very little is known about its effects on the fetus or the fetal brain. Recent data have suggested that sound stimulation causes marked increases in fetal glucose metabolism throughout the cerebral cortex. In addition, studies in the normally oxygenated adult suggest that stimulation-induced increases in glucose consumption are metabolized anaerobically. Application of sound to the fetus may thus result in local lactate production by the fetal brain which may be deleterious to the fetus. Fetal sheep will be chronically catheterized and microsphere measurements of cerebral blood flow will be made with and without the application of a sound stimulus. Arteriovenous differences for glucose, oxygen, and lactate will be obtained and cerebral net fluxes calculated. In addition, the behavioral response will be assessed by measurement of heart rate, electroencephalogram, and limb and nuchal electromyograms. The development of the cerebral response will be investigated in terms of gestational age. Fetal habituation to the stimulus will be characterized and the metabolic consequences of habituation will be explored. The fetal response to sound will be determined during and after ischemia, a time when a dissociation between behavioral and metabolic responses has been observed in the adult. The goals are a.) to build a base of knowledge of the cerebral metabolic and behavioral responses to sound in order to more fully evaluate the clinical utility and safety of the use of sound as a tool to diagnose fetal well-being and b.) to utilize sound stimulation as a model of sensory activation to determine the contribution of anaerobic metabolism to total glucose consumption during physiologic and pathological circumstances as a result of stimulation.