Clarifying Shared and Unique Neurocognitive Processes across Depression and Dementia

晚年的抑郁特征经常与认知能力下降同时出现，但临床医生通常将其视为不同的特征。尽管如此，抑郁症状会增加患痴呆症的风险，这表明疾病轨迹有一定程度的重叠。该项目将应用新的分析方法来阐明抑郁症患者认知能力下降的神经生物学预测因素，并对抑郁症和痴呆症患者中常见和独特的基于大脑的生物标记物进行量化。

Depressive features in late-life frequently co-occur with cognitive decline, but are often treated by clinicians as distinct. Despite this, depressive symptoms increase the risk of dementia, suggesting a degree of overlap in illness trajectories. This project will apply novel analytic methods to clarify neurobiological predictors of cognitive decline in those with depression, and quantify common and unique brain-based biomarkers across those with established depression and dementia.