NAMRA - Network for Antimicrobial Resistance Action

尽管生物医学科学家尽了最大的努力来对抗微生物，但微生物仍在不断进化出耐药性菌株。这将我们带向一个未来，在那里日常操作和感染成为高风险，我们不能在全球范围内生产足够的食物（在美国70%的抗生素用于动物食品生产）。需要一个新的战略来对抗抗生素耐药性（AMR）。该网络将吸收世界领先的工程和物理科学（EPS）研究人员，并将他们引入新的抗菌素耐药性行动网络（NAMRA）。在一系列结构化的活动中，他们将与NHS的临床医生，生物医学科学家以及健康和生命科学的研究人员分享他们的专业知识。这些人可以告诉EPS研究人员需要解决的AMR问题，以及如何设计任何解决方案，以便在现实环境中供医疗保健工作者，农民，工业和工作场所使用。为了帮助实现这一目标，该网络还包括来自社会和人文科学的主要研究人员，他们可以解释AMR解决方案必须如何适应人类行为，地理学家是沃茨分配和畜牧业如何影响AMR的专家;法律的和伦理问题专家，他们开发了AMR的新解决方案，供更广泛的世界使用; EPS的研究人员开发了许多世界领先的技术，从屡获殊荣的StarStream清洁产品，到通过模仿鲨鱼皮肤保持清洁的表面。这些技术是为其他部门（国防、核等）开发的。将这些专业知识转化为对抗抗生素耐药性至关重要。在NAMRA内，发明者可以接触到了解AMR的专家，并访问实验室和诊所，以测试他们合作确定的逐步改变的解决方案。反过来，通过与NAMRA的联系，可以加强当前AMR研究人员的世界领先工作，以便：-设计解决方案; -制定解决方案，供保健工作者和其他人随时采用; -制定采用这些方案的行为、道德和法律的框架;开发业务解决方案，而不是停留在实验室工作台上，逐步改变的技术可以被塑造成产品，在英国和其他地方都可以买到。该项目以“启动”会议开始，与会者可以分享专业知识并确定可能的合作者。分组会议促进了对NAMRA的合作投标，以资助3-6个月的项目，以探索新的想法。一年后，“社区扩展”会议回顾了迄今为止合作的成功，计划新的合作，并邀请来自英国各地的AMR工作人员以及NHS，Gov和当地Gov的代表讨论进展情况。我们将每月为NAMRA内较小的分组举行会议，讨论AMR的具体议题。我们将开发一个认知计算设施，以确定知识差距和可能富有成效的合作领域，与指导委员会一起进行评估。我们还将努力工作，确保在NAMRA两年资助到期后，我们能够维持该网络。为此采取的措施包括提供支持、培训和指导：-确保跨学科研究人员在发表或申请赠款时不会“陷入学科之间的裂缝”; -团队组建一个关于抗生素耐药性的公开展览，涵盖洗手、生物膜和抗生素的使用等问题; -确定并申请资金来源，以继续他们的合作（包括：同行审查提案）;- 通过网站、学校参观、科学博览会向公众宣传他们的工作; -向AMR的下一代领导者。该项目以“Way Ahead”会议结束，以确保在资金停止后继续开展良好的工作。

Microbes continually evolve antibiotic-resistant strains despite the best efforts of biomedical scientists to combat them. This is taking us towards a future where routine operations and infections become high-risk, and where we cannot produce sufficient food globally (70% of antibiotics in the USA are used in animals for food production).A new strategy is needed to combat Antimicrobial Resistance (AMR). This network will take world-leading Engineering and Physical Science (EPS) researchers and introduce them into a new Network for Antimicrobial Resistance Action (NAMRA). In a series of structured events, they will share their expertise with clinicians from the NHS, with biomedical scientists, and researchers from Health and Life Sciences. These people can tell the EPS researchers about the AMR problems that need tackling, and how any solutions must be designed to work in a real-world environment for use by healthcare workers, farmers, industry and the workplace. To help in this, the Network also includes leading researchers from Social and Human Sciences who can explain how AMR solutions must fit in with human behaviour, with Geographers who are experts in how distribution of the waters supply, and how livestock practices, affect AMR; with experts in the Legal and Ethical issues in developing new solutions to AMR for use in the wider world; and with experts in Business who research how supply chain issues affect AMR.The EPS researchers have developed many world leading technologies, from the award-winning StarStream cleaning product, to surfaces that keep clean by mimicking shark skin. Such technologies were developed for other sectors (defence, nuclear etc.) and it is vital that such expertise be translated into the fight against AMR. Within NAMRA, the inventors can access the experts who understand AMR, and access laboratories and clinics to test the step-changing solutions they collaboratively identify. In return, world-leading work by current AMR researchers can be enhanced through NAMRA contacts to: -engineer solutions; -shape them for ready adoption by healthcare workers and others; -set out the behavioural, ethical and legal framework for their adoption; and -develop the business solutions so that, rather than staying on the laboratory bench, step-changing technologies can be fashioned into products that are available across the UK, and beyond. The project begins with a 'Start-up' conference for attendees to share expertise and identify possible collaborators. Break-out sessions facilitate collaborative bids for NAMRA to fund 3-6 month projects to explore new ideas. One year in, a 'Community expansion' conference reviews the success of the collaborations to date, plans new collaborations, and invites AMR workers from across the UK, and representatives from NHS, Gov and local Gov, to discuss progress. We will hold monthly meetings on particular AMR topics for smaller sub-groups within NAMRA. We will develop a Cognitive Computing facility to identify the knowledge gaps and possible fruitful areas of collaboration, working alongside the Steering Committee which performs its own assessment. We will also work hard to ensure that, after the two years of funding for NAMRA expires, we can sustain the network. Measures to do this include offering support, training and guidance: -to ensure that interdisciplinary researchers do not 'fall into the cracks' between disciplines when publishing or applying for grants; -to team-build an exhibit for public display on AMR, covering such issues as handwashing, biofilms and the use of antibiotics; -identify and apply for sources of funding to continue their collaborations (incl. peer-reviewing proposals); -to communicate their work to the public, via websites, school visits, Science Fairs; -to the next generation of leaders in AMR.The project ends with a 'Way Ahead' conference to ensure the good work continues after this funding ceases.