Sheffield antimicrobial resistance network - SHAMROK

20世纪40年代，S引入了抗生素，使医疗保健发生了革命性变化，并在本世纪余下的时间里支撑了医学进步，但70多年后，我们现在面临着越来越多的抗菌素耐药性案例，威胁到许多挽救生命的治疗方法。为这些挑战开发新的创新解决方案的问题来自多个领域，从缺乏对解释抗菌剂作用模式的基础科学的理解，到了解新疗法开发中的临床瓶颈。如果我们要成功地开发新的治疗方法，并保持我们目前在战胜细菌感染的战争中岌岌可危的地位，我们需要充分了解和应对这些挑战。要做到这一点，将需要创新的方法，吸收物理科学和工程学的专业知识和尖端方法，与生物学家和临床医生合作。谢菲尔德大学在细菌研究方面处于世界领先地位，从微生物学到疫苗开发和临床实践，以及生物学家、医生、化学家、物理学家和工程师为解决这些问题而密切合作的良好记录。然而，从更广泛的角度来看，通过鼓励和发展新的研究合作，该大学可以提供更多的东西，这些合作将使工程和物理科学领域的人员充分参与，有可能帮助绕过瓶颈和问题。该项目旨在开发一个框架，以培育和开发新的研究机会，以增强作为我们国际领先的想象：成像生活和弗洛里研究所的一部分的现有研究机会。我们将建立一个广泛的跨院系网络，专注于我们最有能力应对的EPSRC定义的挑战：开发了解细菌学和宿主反应的物理和物理化学工具(“了解细菌学的工具”)；开发新的表面、敷料和组织工程相关方法，以预防感染和提供抗菌剂(“改进的抗菌剂药物输送策略”和“预防感染的智能表面和敷料”)。一系列有重点的研讨会、学科跳跃研究和短期概念验证研究项目将为全球问题提供新的合作和解决方案。我们的目标是既利用明显的协同效应，又积极深入地寻找新的机会，最大限度地利用我们现有的专业知识来催化不受传统学科界限限制的真正变革性的活动。

The introduction of antibiotics in the 1940's revolutionised healthcare and underpinned medical advances through the rest of the century, but little over 70 years later we now face increasing instances of antimicrobial resistance that threaten many life-saving treatments. Problems with developing new innovative solutions to these challenges come from areas as diverse as a lack of understanding of the fundamental science explaining the mode of action of antimicrobials, to understanding clinical bottlenecks in the development of new treatments. If we are to be successful in developing new treatments and maintain our current precarious position in winning the war against bacterial infection, we need to understand and address these challenges fully. To do this will require innovative approaches that draw in expertise and cutting-edge methodology from the physical sciences and engineering, working in partnership with biologists and clinicians. The University of Sheffield has world-leaders in bacterial research, from microbiology to vaccine development and clinical practice, and a proven track record of close collaboration between Biologists, Medics, Chemists, Physicists and Engineers to address these problems. However, looking more widely the University has considerably more to offer through encouraging and developing new research collaborations that will fully engage those in Engineering and the Physical Sciences with the potential to help circumvent bottlenecks and problems.This project aims to develop a framework to nurture and develop new research opportunities to augment those already in place as part of our internationally leading Imagine: Imaging Life and Florey Institutes. We will build an expansive, cross Faculty network that will focus on the EPSRC defined challenges we are best placed to address: the development of physical and physicochemical tools for understanding bacteriology and the host response ("Tools for understanding bacteriology"); and the development of new surfaces, dressings, and tissue engineering related approaches for preventing infections and delivering antimicrobials ("Improved drug delivery strategies for antimicrobials" and "Smart surfaces and dressings to prevent infection"). A series of focussed workshops, discipline hopping research and short proof-of-concept research projects will deliver new collaborations and solutions to a worldwide problem. We will aim to both take advantage of obvious synergies and to actively search deeper for new opportunities, making the most of our existing expertise to catalyse truly transformative activities that are unconstrained by traditional discipline boundaries.