Sheffield antimicrobial resistance network - SHAMROK

谢菲尔德抗菌素耐药性网络 - SHAMROK

• 批准号: EP/M027430/1
• 负责人: Jamie Hobbs
• 金额: $ 64.94万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM027430%2F1
• 关键词: Sheffield; antimicrobial; resistance; network; SHAMROK

The introduction of antibiotics in the 1940's revolutionised healthcare and underpinned medical advances through the rest of the century, but little over 70 years later we now face increasing instances of antimicrobial resistance that threaten many life-saving treatments. Problems with developing new innovative solutions to these challenges come from areas as diverse as a lack of understanding of the fundamental science explaining the mode of action of antimicrobials, to understanding clinical bottlenecks in the development of new treatments. If we are to be successful in developing new treatments and maintain our current precarious position in winning the war against bacterial infection, we need to understand and address these challenges fully. To do this will require innovative approaches that draw in expertise and cutting-edge methodology from the physical sciences and engineering, working in partnership with biologists and clinicians. The University of Sheffield has world-leaders in bacterial research, from microbiology to vaccine development and clinical practice, and a proven track record of close collaboration between Biologists, Medics, Chemists, Physicists and Engineers to address these problems. However, looking more widely the University has considerably more to offer through encouraging and developing new research collaborations that will fully engage those in Engineering and the Physical Sciences with the potential to help circumvent bottlenecks and problems.This project aims to develop a framework to nurture and develop new research opportunities to augment those already in place as part of our internationally leading Imagine: Imaging Life and Florey Institutes. We will build an expansive, cross Faculty network that will focus on the EPSRC defined challenges we are best placed to address: the development of physical and physicochemical tools for understanding bacteriology and the host response ("Tools for understanding bacteriology"); and the development of new surfaces, dressings, and tissue engineering related approaches for preventing infections and delivering antimicrobials ("Improved drug delivery strategies for antimicrobials" and "Smart surfaces and dressings to prevent infection"). A series of focussed workshops, discipline hopping research and short proof-of-concept research projects will deliver new collaborations and solutions to a worldwide problem. We will aim to both take advantage of obvious synergies and to actively search deeper for new opportunities, making the most of our existing expertise to catalyse truly transformative activities that are unconstrained by traditional discipline boundaries.

20世纪40年代抗生素的引入彻底改变了医疗保健，并在世纪的其余时间里巩固了医学进步，但70多年后，我们现在面临越来越多的抗菌素耐药性，威胁着许多挽救生命的治疗。开发新的创新解决方案来应对这些挑战的问题来自不同的领域，如缺乏对解释抗菌剂作用模式的基础科学的理解，以了解新疗法开发中的临床瓶颈。如果我们要成功地开发新的治疗方法，并保持我们目前在赢得细菌感染战争方面的不稳定地位，我们需要充分理解和应对这些挑战。要做到这一点，需要创新的方法，从物理科学和工程学中汲取专业知识和尖端方法，与生物学家和临床医生合作。谢菲尔德大学在细菌研究方面拥有世界领先者，从微生物学到疫苗开发和临床实践，以及生物学家，医生，化学家，物理学家和工程师之间密切合作以解决这些问题的良好记录。然而，从更广泛的角度来看，通过鼓励和发展新的研究合作，大学可以提供更多的东西，这些合作将充分吸引那些在工程和物理科学领域的人，以帮助克服瓶颈和问题。这个项目旨在制定一个框架，以培育和发展新的研究机会，以增强那些已经到位的研究机会，作为我们国际领先的Imagine：成像生活和弗洛里研究所。我们将建立一个广泛的跨学院网络，专注于EPSRC定义的挑战，我们最有能力解决：物理和物理化学工具的开发，以了解细菌学和宿主反应。（“了解细菌学的工具”）;以及新表面、敷料、和组织工程相关的方法来预防感染和递送抗微生物剂（“改进的抗菌药物药物输送策略”和“预防感染的智能表面和敷料”）。一系列重点研讨会，跨学科研究和简短的概念验证研究项目将为全球性问题提供新的合作和解决方案。我们的目标是既利用明显的协同效应，又积极深入地寻找新的机会，充分利用我们现有的专业知识，推动真正的变革性活动，不受传统学科界限的限制。

项目成果

Suicidal chemotaxis in bacteria.

• DOI: 10.1038/s41467-022-35311-4
• 发表时间: 2022-12-09
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Oliveira, Nuno M.;Wheeler, James H. R.;Deroy, Cyril;Booth, Sean C.;Walsh, Edmond J.;Durham, William M.;Foster, Kevin R.
• 通讯作者: Foster, Kevin R.

Direct Imaging of Protein Organization in an Intact Bacterial Organelle Using High-Resolution Atomic Force Microscopy.

使用高分辨率原子力显微镜在完整细菌细胞器中直接对蛋白质组织进行直接成像。

• DOI: 10.1021/acsnano.6b05647
• 发表时间: 2017-01-24
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Kumar S;Cartron ML;Mullin N;Qian P;Leggett GJ;Hunter CN;Hobbs JK
• 通讯作者: Hobbs JK

Tracking bacteria at high density with FAST, the Feature-Assisted Segmenter/Tracker.

• DOI: 10.1371/journal.pcbi.1011524
• 发表时间: 2023-10
• 期刊: PLoS computational biology
• 影响因子: 4.3

Molecular imaging of glycan chains couples cell-wall polysaccharide architecture to bacterial cell morphology.

• DOI: 10.1038/s41467-018-03551-y
• 发表时间: 2018-03-28
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Turner RD;Mesnage S;Hobbs JK;Foster SJ
• 通讯作者: Foster SJ

Reconfigurable Microfluidic Circuits for Isolating and Retrieving Cells of Interest.

• DOI: 10.1021/acsami.2c07177
• 发表时间: 2022-06-08
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Deroy, Cyril;Wheeler, James H. R.;Rumianek, Agata N.;Cook, Peter R.;Durham, William M.;Foster, Kevin;Walsh, Edmond J.
• 通讯作者: Walsh, Edmond J.