CELLULAR RESISTANCE TO VIRAL INFECTION

我们将继续沿着我们的研究所开辟的有希望的道路前进， 弹状病毒两个主要成分的分析：核衣壳 基因组及其聚合酶，以及病毒体包膜（膜）及其 活性成分 我们正在研究VS病毒转录的控制， 复制的 我们将继续研究VS病毒 中断细胞RNA合成，从细胞核转运，加工， 多聚腺苷酸化和多聚核糖体形成。 我们正在继续研究 VS病毒温度敏感突变体及其致病性， 小鼠免疫原性。 我们正试图确定 基质（M）蛋白的亲和标记。 合作研究将 继续与生物化学系的同事们一起。 我们将登上 利用病毒膜的结构和功能进行正面攻击， 精细的化学和生物物理技术。 这些研究应阐明 病毒感染的膜-膜相互作用机制和病毒 发芽

We shall continue on the promising paths opened up by our research into the analysis of the two principal components of rhabdoviruses: the nucleocapsid genome and its polymerase enzymes, and the virion envelope (membrane) and its active components. We are investigating controls of VS viral transcription and replication. We will continue to examine the mechanisms by which VS virus interrupts cellular RNA synthesis, transport from the nucleus, processing, polyadenylation and polyribosome formation. We are continuing studies on temperature-sensitive mutants of VS virus and their pathogenicity and immunogenicity for mice. We are attempting to determine the lipid association of the matrix (M) protein by affinity labeling. Collaborative studies will continue with colleagues in the Biochemistry Department. We shall mount a frontal attack on the structure and function of viral membranes by use of refined chemical and biophysical techniques. These studies should elucidate the mechanisms of virus infection by membrane-membrane interaction and of virus budding.