Clinical and molecular analyses of nodular melanoma

我们对黑素瘤生物学的理解最近取得了一些进展，这些进展现在已经准备好对患有这种疾病的患者的预后产生重大影响。结节亚型黑色素瘤对黑色素瘤死亡率的贡献不成比例。通过使用最新的分子技术来研究这些黑素瘤，我将确定与这些预后不良的黑素瘤相关的致病因素，诊断特征和分子谱，从而为这些黑素瘤的预防，早期发现和治疗提供新的方法。

There have been very recent advances in our understanding of the biology of melanoma that are now poised to have major impacts in the outcome of patients with this disease. The nodular subtype of melanoma contributes disproportionately to mortality from melanoma. By using the latest molecular techniques to study these melanomas I will identify causative factors, diagnostic features and molecular profiles associated with these poor-prognosis melanomas leading to new approaches in the prevention, early detection and treatment of these melanomas.