Clinical and Microbiological Studies of Faecal Microbiota Transplantation in Ulcerative Colitis - A Phase II, Multicentre, Randomised Double Blind, Exploratory Proof of Concept, Placebo Controlled Trial

溃疡性结肠炎(UC)是一种影响大肠的慢性炎症性疾病。这是免疫系统功能失调的结果，免疫系统不适当地瞄准并损害结肠。越来越多的证据表明，肠道细菌在UC中发挥着关键作用，可能是通过刺激免疫细胞的不适当激活。我们相信，通过将健康人的粪便(从而肠道微生物)“移植”到UC患者的结肠中，我们可以改变细菌构成，纠正不适当的免疫系统激活。

Ulcerative Colitis (UC) is a chronic inflammatory condition affecting the large bowel. It is the result of a dysfunctional immune system that inappropriately targets and damages the colon. There is increasing evidence that gut bacteria play a crucial role in UC, possibly by stimulating inappropriate activation of immune cells. We believe that by "transplanting" the faeces (and thus gut microbes) of healthy individuals into the colon of UC patients, we may change the bacterial make up and correct the inappropriate immune system activation.