DESIGN AND EVALUATION OF A HOLLOW VISCUS PROSTHESIS

这项拟议的研究旨在开发和评估一种方法 用允许初级粘膜的假体替换中空内脏 愈合并将假体纳入愈合过程。 全厚离体肠段愈合为2种空洞 内脏假体将在狗身上进行评估。两种类型的假体都将 由外部刚性网状物和可生物降解的中间层组成。《类型》 假体将有一个内部防渗层；B型假体 不会的。假体将在不同的植入后进行评估 时间最长为60天，包括60天。创面愈合模式的评价 假体与粘膜再生、感染、结缔组织 大体光镜和电子显微镜下的内生、排斥和狭窄 将会被执行。

This proposed study is designed to develop and evaluate a method of replacing a hollow viscus with a prosthesis that allows primary mucosal healing and incorporation of the prosthetic into the healing process. Healing of a full thickness isolated bowel segment to 2 types of a hollow viscus prosthesis will be evaluated in dogs. Both types of prosthesis will consist of an outer rigid mesh and a biodegradable middle layer. The Type A prosthesis will have an inner impervious layer; the Type B prosthesis will not. The prostheses will be evaluated at various post-implantation times of up to and including 60 days. Evaluation of healing patterns of the prostheses and mucosal regeneration, infection, connective tissue ingrowth, rejection and stricture by gross light and electron microscopy will be performed.