SYNTHESIS OF ANALOGS OF FREDERICAMYCIN A

第一阶段提案的目标是发现新的 抗肿瘤剂可以提供治疗优势， 那些目前可用的。 这项研究计划将 基于某些类似物的化学合成， 抗肿瘤抗生素弗雷德里克霉素A 这些类似物可以 具有更大的效力，更好的药物递送特性，并且 副作用比天然产品少。 此外，本发明还提供了一种方法， 在第一阶段研究中合成的类似物可能提供线索， 弗雷德里克霉素A的生化作用机制。 在这项工作中取得的任何进展都将创造一个 一个令人兴奋的，深入的第二阶段计划的坚实基础。

The objective of this phase I proposal is to discover novel antitumor agents which may offer therapeutic advantages over those which are currently available. This research program will be based on the chemical synthesis of certain analogs of the antitumor antibiotic fredericamycin A. These analogs may possess greater potency, better drug delivery properties, and fewer side effects than the parent natural product. In addition, the analogs synthesized in this phase I study may provide clues as to the biochemical mechanism of action of fredericamycin A. Any advances made during the course of this work will create a solid foundation for an exciting, indepth phase II program.