LASER CATHETER ULTRASONIC IMAGING SYSTEM

这个项目的目标是开发一个原型导管- 安装超声波换能器，可用于引导激光 使用通过光纤传送的光的外科手术 导尿管 激光手术可以精确消融病变， 肿瘤、动脉粥样硬化斑块和血管畸形. 其他技术无法访问的网站。 但据 也相对容易损伤邻近或 在病变的下方，或在中空处造成穿孔 结构. 这些并发症可以避免与原位 关于特征和厚度的诊断信息， 靶组织和热变性的程度 激光能量 超声波成像（即使是简单的，一个- 更有可能提供这种信息，而不是 光学或放射技术。 本阶段的具体目标 我的建议是建造和评估一个微型超声波 传感器的分辨率小于100微米， 成像深度小于1 cm，可与 侧发射光纤以确定损伤厚度， 控制消融。 传感器将在模型系统中进行测试 以及在体外的动物和人体组织中。

The goal of this project is to develop a prototype catheter- mounted ultrasonic transducer which could be used to direct laser surgery procedures which use light delivered through fiber optic catheters. Laser surgery allows precise ablation of lesions such as tumors, atherosclerotic plaques and vascular malformations at sites which are inaccessible by other techniques. However, it is also relatively easy to damage normal tissues adjacent to or underlying the lesions, or to cause perforations in hollow structures. These complications might be avoided with in situ diagnostic information about the character and thickness of the target tissue and the extent of thermal denaturation caused by the laser energy. Ultrasonic imaging (even simple, one- dimensional) is more likely to provide this information than are optical or radiological techniques. The specific aims of this Phase I proposal are to construct and evaluate a miniature, ultrasonic transducer with a resolution of less than 100 micron and an imaging depth less than 1 cm which could be combined with a side-emitting optical fiber to determine lesion thickness and control ablation. The transducer will be tested in model systems and in animal and human tissues in vitro.