PROTECTIVE TREATMENT FOR CATHETERS

长期目标： 使中心静脉导管(CVC)商业化 它们已经过化学处理以减少它们的倾向 引发感染，从而带来重大的人道主义利益 以及大幅降低医院护理成本。 具体目标和方法： (1)应用已经开发的抗菌工艺 硅橡胶对常用CVC的防护(希克曼) 设备； (2)确定抗微生物活性的持续时间和水平 在生理盐水灌流期间进行最佳处理的导管， 营养和肿瘤治疗解决方案； (3)确定处理过的导管的保护程度 通过上述(2)中使用的方法，在体外对抗管腔定植； (4)测定各处理组小鼠组织的生物相容性。 导管材料； (5)测定正常储藏对抗菌效果的影响 经处理的导管的活性和抗张强度。

Long Term Objective: To make commercially available central venous catheters (CVC) which have been chemically treated to reduce their tendency to induce infections thereby bringing major humanitarian benefits and substantial reductions in hospital care costs. Specific Aims and Methodology: (1) apply an already developed process for antimicrobial protection of silicone rubber to a commonly used CVC (Hickman) device; (2) determine the duration and levels of antimicrobial activity of optimally treated catheters during perfusion with saline, nutritional, and oncotherapeutic solutions; (3) determine the degrees of protection of treated catheters against lumen colonization in vitro, by methods used in (2) above; (4) determine the biocompatibility in mouse tissue of the treated catheter material; (5) determine the effects of normal storage on antibacterial activity and tensile strength of treated catheters.