MAGNETIC GELATIN PARTICLES FOR TUMOR DETECTION

第一阶段SBIR提案的目的是开发一种3微米的 用于肿瘤检测的稳定微泡， 超声. 该提案基于微泡技术， 由PI于1976年发起，并一直持续至今。 明胶包裹的微泡粘附在异常血管壁上。 因为气泡起着超声波反射器的作用， 微泡可以用临床超声可视化， 它们将有效地检测小肿瘤。 这种泡沫的作用 作为位点特异性肿瘤标记物，当它们粘附于肿瘤血管壁时， 长达15分钟，但进入正常组织的微泡溶解， 几分钟内清除。 为了给临床医生提供一些控制 在微泡上，生物相容性氧化铁，其能够 被磁体移动，将被添加到气泡壁。 因此，在本发明中， 使用超声波，临床医生可以观察起泡剂， 磁引导，以便将它们集中在目标区域。 第一阶段工作的主要目标是形成一个气泡 能够产生3微米明胶包封的微泡的发生器。 第二阶段的活动将旨在量化和优化 该技术在体内与植入和自发性肿瘤。

The purpose of this Phase I SBIR proposal is to develop a 3 micron stabilized microbubble for tumor detection when used in conjunction with ultrasound. This proposal builds on a microbubble technology that originated in 1976 by the PI and has continued since that time. Gelatin encapsulated microbubbles adhere to abnormal vessel walls. Because bubbles act as ultrasonic reflectors, small quantities of microbubbles can be visualized with clinical ultrasound, and it is hoped that they will be effective in detecting small tumors. Such bubbles act as site-specific tumor markers when they adhere to tumor vessel walls for up to 15 minutes, but microbubbles entering normal tissue dissolve and clear in minutes. In order to provide the clinician with some control over the microbubbles, a biocompatible iron oxide, which is capable of being displaced by a magnet, will be added to the bubble wall. Thus, using ultrasound, the clinician can observe the bubble agents while under magnetic guidance in order to concentrate them in the target area. The primary goal of the proposed Phase I effort is to develop a bubble generator capable of producing 3 micron gelatin encapsulated microbubbles. Phase II activities will be aimed at quantification and optimization of the technique in vivo with implanted and spontaneous tumors.