MASS SPECTROMETRIC SURFACE ANALYSIS OF MEMBRANES

描述（改编自申请人摘要）：I期研究将 评估使用飞行时间二次离子质量的可行性 光谱分析（TOF-SIMS），以提供灵敏的和结构上重要的 生物膜表面组成的表征。 的 研究将分析各种模型膜系统，以充分 评估这种可行性。 本研究产生的数据将 特别评价其诊断价值， 膜化学结构 这项研究的长期目标是开发常规， 化学分析的定量表面分析技术 膜表面 实现这一目标可能需要广泛的 应用于各种生物科学，包括合成 膜的发展，膜的基础研究 结构/功能关系，并可能更好地了解 生物膜在生物体健康状态中的作用。

DESCRIPTION (Adapted from Applicant's Abstract):The Phase I research will evaluate the feasibility of using time-of-flight secondary ion mass spectrometry (TOF-SIMS) to provide sensitive and structurally significant characterization of the surface composition of biological membranes. The research will analyze a variety of model membrane systems in order to fully evaluate this feasibility. The data produced in this study will be evaluated specifically with regard to its diagnostic value in elucidation membrane chemical structure. The long term objective of this research is to develop routine, quantitative surface analysis techniques for the chemical analysis of membrane surfaces. The achievement of this objective could find extensive application in a variety of biological sciences including synthetic membrane development, fundamental investigations of membrane structure/function relationships and possibly, better understanding of the role biomembranes play in the state of health of organisms.