DEVELOPMENT OF A NOVEL TTS--MEMBRANE OPTIMIZATION

描述：(改编自申请人的摘要)。这项建议 介绍了一种新型脉冲透皮材料的化学研究进展 使用现有的概念化Intlimer TM的治疗系统(TTS) 兰迪克实验室专有的聚合物膜。最终，该系统将 启用脉冲式、斜坡式和日间给药方案。潜在的好处 从这样的系统派生出的公差包括减少、改进 患者依从性和患者控制治疗。 脉冲透皮系统的核心是Intlimer TM级 聚合物控制释放材料。这些聚合物具有非常低的 对多种药物的渗透性低于“开关温度”和非常 高于该温度的高渗透性。在这里要做的工作 研究建议将重点放在优化这些聚合物和膜 从他们那里做好准备。选定的模型药物化合物通过 膜将作为温度的函数进行测量。扩散 将计算参数，这些结果将用于修改和 优化聚合物材料以达到所需的“开关温度” 和释放率。最后，将建立层压技术，并 将测量叠层装置的体外释放曲线。

DESCRIPTION: (Adapted from the Applicant's Abstract). This proposal describes the chemical development of a novel pulsed transdermal therapeutic system (TTS) using existing and conceptualized Intelimer TM polymeric membranes proprietary to Landec Labs. Ultimately, the system will enable pulsed, ramp, and diurnal dosing regimens. Potential benefits derived from such a system include the reduction of tolerance, improved patient compliance, and patient controlled therapy. The heart of the pulsed transdermal system is the Intelimer TM class of polymeric controlled release materials. These polymers have a very low permeability to a variety of drugs below a "switch temperature' and a very high permeability above that temperature. The work to be performed in this research proposal will focus on optimizing these polymers and the membranes prepared from them. The flux of selected model drug compounds through the membranes will be measured as a function of temperature.Diffusion parameters will be computed and these results will be used to modify and optimize the polymer materials to achieve the desired "switch temperature" and release rate. Finally, laminating techniques will be established and in vitro release profiles of the laminated device will be measured.