DNA PROBES TO DETECT PREDISPOSITION TO TYPE I DIABETES

肝脏疾病是一个主要的健康问题。诊断性 预测肝功能衰竭的技术可以用以下方面来解释 整体肝功能，而不是在解剖结构方面。 关于肝脏的解剖信息已通过使用 放射性胶体。这些材料被Kupffer采用 肝细胞(占肝脏质量的3%)，而不是肝细胞(90%) 质量)，肝脏的主要代谢细胞。电流成像 包括MR和CT在内的检查方法在 定义正常运作的肝脏体积。为了克服这些诊断 半乳糖的限制、合成与表征 含有磁性标记的蛋白质(包括可溶性和 颗粒物)是计划中的。这些蛋白质被定向到 半乳糖对肝细胞去唾液酸糖蛋白受体的影响 预计会显著影响组织的质子弛豫速率和 从而在磁共振图像上定义功能性肝脏肿块。受体 靶向磁共振造影剂代表了一种技术上的新奇 和潜在的一般方法来设计磁共振对比图 探员们。

Diseases of the liver are a major health problem. Diagnostic techniques to predict liver failure are interpretable in terms of overall liver function, not in terms of anatomic structure. Anatomical information on liver has been obtained by using radioactive colloids. These materials are taken up by Kupffer cells (3 % of liver mass) and not by hepatocytes (90%) of liver mass), the main metabolizing cell of the liver. Current imaging modalities including MR and CT are also of limited usefulness in defining functioning liver volumes. To overcome these diagnostic limitations, the synthesis and characterization of galactose containing magnetically labelled proteins (both soluble and particulate) is planned. These proteins, directed to the asialoglycoprotein receptor of hepatocytes by galactose, are expected to significantly effect tissue proton relaxation rates and thereby define functioning liver masses on MR images. Receptor targeted MR contrast agents represents a technologically novel and potentially general approach to the design of MR contrast agents.