NATURAL PRODUCT DRUG FROM STRESSED MARINE INVERTEBRATE

这个项目的目标是开发引起从头开始的方法。 包被海洋合成生物活性化学物质 并测试这些“标签代谢物”(=化感物质) 抗肿瘤活性。这些方法旨在确定潜在的 在给定的底栖生物生态系统内产生“标签代谢物”，并且可以 纳入正在进行的系统海洋生物采集 旨在提高工作效率的计划。以下代表 无脊椎动物Phyla将用于生态压力实验： Porifera(海绵)、Criidaria(珊瑚)、苔藓(外生直肠动物)和 尾索动物(被囊类)。第一阶段将制定出符合生态环境的协议 应激包被海洋无脊椎动物以产生“标签代谢物”。阶段 我将把这些努力扩展到其他地理区域，并进一步 室内培养在田间试验中的应用研究 利用那些产生药理上有趣的生物 化合物；主要候选者将获得专利并向政府发放许可证 或者为了她的发展而卖给制药公司。预计 目标治疗组中具有活性的“标签代谢物”将是 制药业感兴趣的新化合物。

The goal of this project is to develop methods that cause the de novo synthesis of biologically active aIlelochemicals by encrusting marine organisms, and to test these "tag metabolites" (=allelochemicals) for antitumor activity. These methods are designed to determine the potential for "tag metabolite" production within a given benthic ecosystem, and can be incorporated into on-going systematic marine organism acquisition programs to enhance productivity. Representatives of the following invertebrate Phyla will be used in the ecological stress experiments: Porifera (sponges), Criidaria (corals), Bryozoa (ectoprocts), and Urochordata (tunicates). Phase I will develop protocols that ecologically stress encrusting marine invertebrates to produce "tag metabolites". Phase ll will expand these efforts to other geographic regions, and further the investigation by laboratory culture application of the field experiments using those organisms that produce pharmacologically interesting compounds; lead candidates will be patented and licensed to the government or to pharmaceutical companies for her development. It is anticipated that "tag metabolites" with activity in the target therapeutic groups will be novel compounds of interest to the pharmaceutical industry.