AUTOMATED BISENSORS OPERATED UNDER TRANSIENT MODE

本研究的总体目标是开发一种可靠的， 灵敏的单、多二维膜氧电极 系统作为化疗剂的潜在筛选系统。 PBI开发这种溶解气体测量系统的方法是 建立在现有的膜电极设计上，并使用微计算机 和一个内部开发的软件来克服一些问题 与传统的膜电极技术相关。 这种非侵入性技术可用于细胞培养监测， 研究基本的细胞代谢的影响因素， 代谢，并在研究细胞毒性引起的细胞变化， 化合物、激素和其他抗肿瘤药物。 这可以 也可用于检测各种化学品的毒性和安全性 食品中使用的药剂。 它可以应用于临床环境中的测试 不同的药物组合和化疗药物的其它组合 方案. 该技术的体外和体内应用还可以 扩展到生物医学领域，例如监测葡萄糖，pCO2， 血液等

The overall objective of this research is to develop a reliable and sensitive single and multiple two-dimensional membrane oxygen electrode system as a potential screening system for chemotherapeutic agents. PBI's approach to developing this dissolved-gas measurement system is to build on an existing membrane electrode design and to use a microcomputer and an in-house developed software to overcome some of the problems associated with traditional membrane electrode technology. This non-invasive technology can be used in cell culture monitoring in studies on basic cellular metabolism on factors affecting this metabolism, and in studies on cellular changes due to cytotoxic compounds, hormones, and other pharmacologically active drugs. This can also be used to examine the toxicity and safety of various chemical agents used in food. It can be applied in clinical settings in testing different drug combinations and other combinations of of chemotherapeutic regimen. In-vitro and in-vivo applications of this technology can also be extended to the biomedical area, e.g. monitoring glucose, pCO2, in blood , etc.