NOVEL, NEMATODE-SPECIFIC ANTHELMINTICS AND NEMATICIDES

该项目的目标是确定新的驱虫剂和/或 杀线虫剂，通称为抗线虫药物，它有 新的行动模式。该方法由四个步骤组成：1) 鉴定一种对模型线虫有活性的化合物 优雅(在这一步，化合物的效力并不重要)。2) 确定化合物的作用模式是新颖的，使用独特的 技术，称为NemaScreen，它涉及分析 耐药突变体库中每个成员上的化合物。 优雅女装。新化合物被认为是对所有人都有效的化合物 图书馆里的变种人。3)分离新的突变体 对这种新化合物具有抵抗力。4)建立配体结合分析方法 新的靶点和哺乳动物中的同源靶点。新的突变体 为作用于同一化合物的新化合物提供特定部位的筛选 靶标。，配体结合试验促进结构活性 旨在识别线虫专一性化合物的研究。 该方法旨在与主要 制药和/或农用化学品公司。

The goal of this project is to identify new anthelmintics and/or nematicides, referred to generically as anti-nematode drugs, which have novel modes of action. The approach is comprised of four steps: 1) Identify a compound which is active on the model nematode Caenorhabditis elegans (at this step potency of the compound is unimportant). 2) Establish that the compound's mode of action is novel using a unique technology, called NemaScreen, which involves analyzing the efficacy of the compound on each member of a library of drug-resistant mutants of C. elegans. Novel compound are defied as those which are effective on all of the mutants in the library. 3) Isolate new mutants which are resistant to the novel compound. 4) Establish ligand binding assays for the new target and for homologous targets in mammals. The new mutants provide a site-specific screen for new compounds which act on the same target., The ligand binding assays facilitate structure activity studies designed to identify compounds which are nematode specific. The approach is designed to be carried out in collaboration with major pharmaceutical and/or agricultural chemical companies.