CONTINUOUS DELIVERY RIGHT VENTRICULAR ASSIST SYSTEM

这项研究的长期目标是创造一种可植入的 临时右室辅助系统(RVA)优于 现有设备在尺寸、手术复杂性、易用性和 成本。大约30%的脑室辅助应用涉及RVA。 目前的RVA在解剖学上与植入性不相容。还没有 可植入装置通常是长期临时性的理想装置 由于它们感染的可能性较低，因此不能接受手术。 正在进行的SBIR第二阶段赠款(编号1R43HL40272-02)针对的是 提供具有上述特征的左心室辅助系统(LVAS)。 因为它需要低得多的压力上升，所以RVA需要新的刀片 几何图形。这项第一阶段的工作将重点放在叶片几何形状的开发和 通过体外水力和溶血试验和急性中毒进行演示 活体测试。将利用现有的硬件。 主题RVA概念的技术创新在于它提供了一种 利用微型计算机提供有效的右心辅助的方法 植入的泵可以在没有大手术创伤的情况下放置。]

[The long-term objectives of the research is to create an implantable temporary right ventricular assist system (RVAS) which is superior to existing devices with respect to size, surgical complexity, ease of use and cost. Approximately 30% of ventricular assist applications involve a RVAS. Current RVAS's are not anatomically compatible with implantability. Yet implantable devices are frequently desirable for longer-term temporary procedures due to their lower potential for infection. An ongoing SBIR Phase II grant (No. 1R43HL40272-02) is directed at providing a left ventricular assist system (LVAS) with the above features. Because it requires much lower pressure rise, the RVAS requires new blade geometry. This Phase I effort will focus on blade geometry development and demonstration through in vitro hydraulic and hemolysis testing and acute in vivo testing. Existing hardware will be utilized. The technical innovation of the subject RVAS concept is that it offers a method of providing effective right heart assistance with a miniature implanted pump that can be placed without the trauma of major surgery.]