MINIATURE IN-VIVO HYDROPHONES FOR LITHOTRIPTER USE

这项工作的目的是开发一种新的微型精度 能在体内冲击波中存活的声学传感器(水听器) 菲尔德。该装置的直接应用是提高安全性 体外冲击波碎石术(ESWL)治疗肾小球结石疗效观察 肾结石和胆结石。拟议的研究涉及1) 用于检查与材料相关的设计权衡的理论建模 选择和传感器配置；2)材料测试以确定 声学性能和耐久性；3)原型设计和组装；4) 声学性能表征；以及5)在以下条件下的生存测试 冲击波条件。当在第二期下全面发展时， 水听器将用于ESWL治疗的体内监测。这个 水听器将是小(1 mm直径)，宽带(100 MHz带宽)， 近乎全方位(&gt；90度捕捉角度)，并且足够坚固，足以生存 反复的冲击波。它将有助于在以下方面取得重大进展 从结石机制的角度进行碎石治疗 破坏和组织损伤，提高治疗效果，减少 患者创伤，规范新的碎石技术。超越 水听器在碎石术中的应用，将对体内和体内有用。 体外诊断超声剂量学、海洋学和其他应用 需要坚固的微型声学传感器。

The purpose of this work is to develop a new class of miniature precision acoustic sensors (hydrophones) which would survive in an in-vivo shock wave field. The immediate application of the device is in improving the safety and efficacy of Extracorporeal Shock Wave Lithotripsy (ESWL) treatment of kidney and gallbladder stones. The proposed research involves 1) theoretical modeling to examine design trade-offs associated with material choice and sensor configuration; 2) materials testing to determine acoustical properties and durability; 3) prototype design and assembly; 4) acoustical performance characterization; and 5) survivability tests under shock wave conditions. When fully developed under Phase II, the hydrophones would be used for in-vivo monitoring of ESWL treatment. The hydrophone will be small (<1mm diameter), wideband (>100MHz bandwidth), nearly omnidirectional (>90o capture angle), and robust enough to survive repeated shock waves. It will contribute to significant advances in lithotripsy treatment, in terms of understanding the mechanism of stone destruction and tissue damage, improving treatment efficacy, reducing patient trauma, and regulating new lithotripsy technology. Beyond lithotripsy applications, the hydrophone will be useful for in-vivo and in- vitro diagnostic ultrasound dosimetry, oceanography, and other applications requiring robust miniature acoustic sensors.