NOVEL, NEMATODE-SPECIFIC ANTHELMINTICS AND NEMATICIDES

该项目的目标是确定新的驱虫剂和/或 杀线虫剂，一般称为抗线虫药物， 新的行动方式。 该方法由四个步骤组成：1） 鉴定对模式线虫小杆线虫有活性的化合物 elegans（在该步骤中，化合物的效力不重要）。 （二） 使用一种独特的方法确定化合物的作用方式是新颖的。 这项技术名为NemaScreen，它涉及分析 该化合物对C. 优雅 新化合物被定义为对所有人有效的化合物。 变种人的资料 3)分离新的突变体， 对新化合物具有抗性。 4)建立配体结合试验， 新靶点和哺乳动物中的同源靶点。 The New Mutants 为作用于相同位点的新化合物提供位点特异性筛选 目标， 配体结合测定促进结构活性 旨在鉴定线虫特异性化合物的研究。 该方法旨在与主要的 制药和/或农用化学品公司。

The goal of this project is to identify new anthelmintics and/or nematicides, referred to generically as anti-nematode drugs, which have novel modes of action. The approach is comprised of four steps: 1) Identify a compound which is active on the model nematode Caenorhabditis elegans (at this step potency of the compound is unimportant). 2) Establish that the compound's mode of action is novel using a unique technology, called NemaScreen, which involves analyzing the efficacy of the compound on each member of a library of drug-resistant mutants of C. elegans. Novel compound are defied as those which are effective on all of the mutants in the library. 3) Isolate new mutants which are resistant to the novel compound. 4) Establish ligand binding assays for the new target and for homologous targets in mammals. The new mutants provide a site-specific screen for new compounds which act on the same target., The ligand binding assays facilitate structure activity studies designed to identify compounds which are nematode specific. The approach is designed to be carried out in collaboration with major pharmaceutical and/or agricultural chemical companies.