THE ROLE OF CHROMIUM DEFICIENCY IN INSULIN RESISTANCE

铬缺乏会导致严重的胰岛素抵抗和葡萄糖 不容忍 美国和其他国家的平均膳食铬摄入量 发达国家处于边缘地位，可能导致高频率的 糖尿病是发达国家的通病。 临床主要铬 评价问题是对铬状况的评价。 测定 铬的状况一直很困难，因为它的生物活性极低， 水平和以前的失败，以确定一个可靠的体液 或组织来评估铬的状态。 在第一阶段，皮肤被假定为 潜在相关组织以评估铬状态。 共振 电离光谱用于证明飞秒灵敏度， 铬和可靠地确定皮肤中的铬浓度 活组织检查 在一项初步研究中， 与对照组相比，发现患者缺乏铬。 同相 II更多的银屑病患者铬缺乏和肥胖铬- 将对足够多的患者进行研究，以证实铬饮食 补充将显着改善胰岛素抵抗的 缺铬组 本研究可望为今后的研究打下坚实的基础 来解决糖尿病中的铬问题， 糖尿病商业诊断评估的基础， 由于缺乏铬，情况变得复杂。

Chromium deficiency causes severe insulin resistance and glucose intolerance. Average dietary chromium intake in the U.S. and other developed countries is marginal and may contribute to the high frequency of diabetes plaguing developed countries. The major clinical chromium evaluation problem is the assessment of chromium status. Determination of chromium status has been difficult because of its extremely low biological levels and the previous failure by others to identify a reliable body fluid or tissue to assess chromium status. In Phase I, skin was postulated as a potentially relevant tissue to assess chromium status. Resonance ionization spectroscopy was used to demonstrate femtogram sensitivities for chromium and to determine reliably chromium concentrations in skin biopsies. In a pilot study the skin of psoriatic, insulin resistant patients compared to controls was found to be chromium deficient. In Phase II a larger population of psoriatic chromium-deficient and obese chromium- sufficient patients will be studied to confirm that chromium diet supplementation will markedly improve the insulin resistance of the chromium deficient group. This study is expected to lay a solid foundation to approach the problem of chromium in diabetes generally, and to initiate the basis for commercial diagnostic assessments of diabetes whose medical situation is complicated by a chromium deficiency.