DECONTAMINATION OF PLATELET CONCENTRATES

这项研究的总体目标是为 去污染浓缩的血小板。想要的方法 会降低病毒感染和细菌败血症的风险 与血小板浓缩物的治疗使用有关。现在时 对捐献的血液进行筛查不会检测到所有潜在的 传染性污染物。因此，重要的是要找到一个 使血液制品具有非特异性和非传染性的方法。 我们建议演示我们停用模型的能力 浓缩血小板中的动物病毒。我们将研究 失活处理对1)总血小板的影响 通过测量作为以下函数的血小板计数的形态 失活时间；2)血小板对聚集剂的反应； (3)用荧光抗体法检测血小板活性。 这项研究有可能在商业上有用 保护大约500万到700万个单位的血小板 每年输血一次。

The overall objective of the research is to define a system for decontaminating platelet concentrates. The desired method would reduce the risk of viral infection and bacterial sepsis associated with therapeutic use of platelet concentrates. Present screening of donated blood will not detect all potentially infectious contaminants. Therefore it is important to find a means of rendering blood products non-specifically non-infectious. We propose to demonstrate our ability to inactivate a model animal virus in platelet concentrates. We will examine the effects of the inactivation treatment on 1) gross platelet morphology by measuring platelet count as a function of inactivation time; 2) response of platelets to aggregating agents; and 3) platelet activation by fluorescent antibody assay. This research has the potential to be commercially useful in safeguarding the estimated 5 to 7 million units of platelets transfused annually.