DEVELOPMENT OF A COMPUTERIZED NASAL RESISTANCE SYSTEM

尽管成千上万的美国人遭受着 过敏、哮喘、息肉病、鼻部畸形和其他呼吸道 限制疾病，目前商业上没有低成本可用 鼻腔气流定量评估的综合计算机系统 功能。基于男性和女性受试者的量化规范数据 鼻功能正常和异常的患者不能采取任何措施 来自当前可用的商业系统的气流，以及所有 这类系统存在许多技术和理论问题。 这个项目的总体目的是为了开发，为后续 商业配送，低成本、实用、一体化的计算机化 具有有效标准数据的鼻腔测量系统。同相 I在这个SBIRP项目中，我们将启动这个系统的开发。 在第二阶段，我们将完成该系统的开发，并建立 鼻功能正常和异常个体的人群常模。 在第三阶段，开发的系统将投入商业使用 分发。在这项提案中，只要求为第一阶段提供资金， 虽然将在第二阶段进行的研究在 研究计划，以提供整个研究策略的概述 程序。

Despite the fact that hundreds of thousands of Americans suffer from allergies, asthma, polyposis, nasal deformities, and other airway restricting maladies, there is presently no low cost commercially available integrated computerized system for quantitatively assessing nasal airflow function. Quantitative normative data based upon male and female subjects with normal and abnormal nasal function are not available for any measures of airflow derived from currently available commercial systems, and all such systems suffer from a number of technical and theoretical problems. The overall purpose of this project is to develop, for subsequent commercial distribution, a low cost, practical, and integrated computerized rhinometric system for which valid normative data are available. In Phase I of this SBIRP project we will initiate the development of this system. In Phase II we will complete the development of this system and establish population norms for individuals with normal and abnormal nasal function. During Phase III the developed system will be made available for commercial distribution. Funding is requested in this proposal for only Phase I, although studies to be conducted in Phase II are briefly mentioned in the Research Plan to provide an overview of the strategy of the entire research program.