Closed-loop insulin delivery compared with islet cell transplantation for adults with type 1 diabetes and impaired awareness of hypoglycaemia

成人1型糖尿病患者的低血糖是很常见的。在一组反复出现低血糖的队列中，有必要对治疗方法进行评估--“人工胰腺”和胰岛细胞移植。这项建议将评估‘人工胰腺’和胰岛细胞移植，与通常的胰岛素治疗相比，是否将在6个月内降低低血糖并改善其他临床结果。这有可能扩大目前临床实践中使用的治疗方法。

Hypoglycaemia in adults with type 1 diabetes is common. Evaluation of therapies – the ‘artificial pancreas’ and islet cell transplantation - is warranted in a cohort with repeated episodes of hypoglycaemia. This proposal will assess whether the ‘artificial pancreas’ and islet cell transplantation, compared with usual insulin therapy, will reduce hypoglycaemia and improve other clinical outcomes over 6 months. This has potential to expand therapies used in current clinical practice.