NEW ULTRATHIN ANGIOSCOPE FOR ATHERECTOMY APPLICATIONS

本提案中提出的研究的长期目标是 开发创新成像仪器的设计，称为 用于动脉粥样硬化切除术的超薄血管镜。述成像装置是 专门设计用于当前的斑块切除术 为了提供高分辨率、三维、真实的 程序的体内时间监测。分钟血管镜将是 通过斑块切除器械的导丝通道插入， 推进和缩回，因为在整个过程中需要不同的内腔视图 程序这种设计的意义在于增加了 它将向医生提供关于患者状况的信息。 动脉系统除了目前使用的二维 血管造影。具体而言，在第一阶段，将建立一个原型系统， 开发，以证明光学的可行性 原则和系统总体设计。原型演示将 包括通过动脉粥样硬化导管插入血管镜 将模型动脉管腔成像到CCD照相机中。潜在应用 对于这种微小的成像系统来说是普遍的。一旦开发出 系统可以与各种心脏 仪器和程序，如球囊血管成形术。

The long term goal of the research presented in this proposal is to develop a design for innovative imaging instrumentation called the Ultrathin Angioscope for Atherectomy Applications. The imaging device is specifically designed to be utilized by current atherectomy instrumentation in order to provide high resolution, 3-dimensional, real time in vivo monitoring of the procedure. The minute angioscope will be inserted through the guidewire channel of the atherectomy instrument and advanced and retracted as different lumenal views are needed throughout the procedure. The significance of this design is the increased information it will provide to the physician about the conditions of the arterial system in addition to the currently used 2-dimensional angiogram. Specifically, in Phase I, a prototype system will be developed in order to demonstrate the feasibility of the optical principles and the overall system design. Prototype demonstrations will include insertion of the angioscope through an atherocath in order to image model arterial lumens into a CCD camera. Potential applications are widespread for such a minute imaging system. Once developed the system can be used in conjunction with a variety of cardiac instrumentation and procedures, such a balloon angioplasty.