REAL TIME OPTICAL FEEDBACK CONTROL OF LASER LITHOTRIPSY

描述(改编自申请人的摘要)： 提出的研究计划是进一步发展这项技术 在第一阶段演示了激光的自动实时反馈控制 碎石术。到目前为止，体外实验结果显示出相当大的希望 利用在此过程中产生的特征的瞬发光发射 激光快速自动反馈控制的脉冲激光碎石术 能量输送。其结果是一种可以显著减少 在保持良好状态的同时，激光损伤健康软组织的风险 结石碎石功效。对这种设备的需求越来越大 显然，临床上使用的激光脉冲能量已经增加，以便 治疗最坚硬的石头。此外，这样的设备将是无价的 在直视有问题的情况下(如在 胆汁树)。 第二阶段工作的具体目标是：1)纳入反馈 将控制装置转化为商用(或研究)脉冲染料激光器 碎石机，2)证明了它的有效性和改进的安全性 在猪身上进行的一系列活体研究中的“智能”设备，以及3) 根据项目2的结果和输入建立最终的设计规范 来自临床医生用户和激光制造商(S)。

DESCRIPTION (Adapted from applicant's abstract): The objective of the proposed research plan is to further the development of the technology demonstrated in Phase I for automated real-time feedback control of laser lithotripsy. In vitro results to date have shown considerable promise for utilizing the characteristic prompt optical emissions generated during pulsed laser lithotripsy for the rapid automatic feedback control of laser energy delivery. The result is a technique which can significantly reduce the risk of laser injury to healthy soft tissue while maintaining good stone fragmentation efficacy. The need for such a device is increasingly evident as laser pulse energies used clinically have increased in order to treat the hardest stones. Further, such a device would be invaluable under conditions where direct vision is problematic (such as occurs in the biliary tree). The specific aims of the Phase II effort are: 1) incorporate the feedback control device into a commercial (or investigational) pulsed dye laser lithotriptor, 2) demonstrate the efficacy and improved safety of this "smart" device in a series of in vivo studies performed in pigs, and 3) establish final design specifications based on results of item 2 and input from clinician users and the laser manufacturer(s).