TOOLS FOR TRANSFORMING AND COMBINING CLINICAL DATA

这项研究的目标是开发一种新的交互软件工具， 名为ClinTrans，帮助生物统计学家转换和组合 临床数据，为数据分析、数据交换和 交叉学习共享。目前，数据准备过程中往往 需要大量的定制编程，从而消耗宝贵的资源 可以用于更重要的数据探索和 口译活动。 在L阶段，我们将收集各种临床数据库的实例 哈佛大学公共卫生学院和其他机构的布局 具有代表性的学术、政府和行业临床研究 中心，我们将研究所需的转换 使布局兼容。在此工作的基础上，我们将设计 ClinTrans工具的详细功能，并将构建初始 软件原型，以帮助评估设计的关键方面。 该项目的主要技术创新是创造了一种新的 数据库转换的计算机辅助方法，具体而言 专为处理临床数据量身定做。与健康相关的主要贡献 是希望提高生产力、速度和可靠性的 准备临床数据进行分析，以支持安全性和 新疗法的疗效评价。

The goal of this research is to develop a new interactive software tool, called ClinTrans, to assist biostatisticians in transforming and combining clinical data in preparation for data analysis, data interchange, and cross-study pooling. Presently, the process of data preparation often requires substantial custom programming, consuming valuable resources that could otherwise be devoted to more important data exploration and interpretation activities. In Phase l, we will collect examples of a variety of clinical database layouts from the Harvard School of Public Health and from other representative academic, government, and industrial clinical research centers, and we will study the transformations that would be required to make the layouts compatible. Based on this work, we will design the detailed capabilities of the ClinTrans tool and will construct an initial software prototype to help evaluate key aspects of the design. The major technical innovation in this project is the creation of a new computer-aided approach to database transformation that is specifically tailored for handling clinical data. The major health-related contribution is hoped to be greater productivity, speed and reliability in the preparation of clinical data for analysis to support the safety and efficacy evaluation of new therapies.