ORGANOSILICON BIOMEDICAL RESEARCH

具体目的是研究其药理学特性 已知活性有机分子的甲硅烷基化衍生物， 鉴定不 都知道碳的类比。 不含碳类似物的活性有机硅化合物似乎 为未来发现新药物提供最大的潜力 化合物. 三个支链有机硅化合物 或四个直接键合到碳或硅原子上的甲硅烷基 在有机化学中没有相似之处，因此， 将致力于研究它们的活动。 此外，已知的化合物的甲硅烷基化衍生物的合成和药理学也是已知的。 药用的将研究化合物以建立 空间填充、亲脂性 甲硅烷基和生物学性质。

The specific aim is to investigate the Pharmacological properties of silylated derivatives of known active organic molecules and to identify biologically active organosilicon compounds that do not have known carbon analogy. Active organosilicon compounds without carbon analogy appears to offer the greatest potential for future discovery of new medicinal compounds. The branched-chain organosilicon compounds with three or four silyl groups directly bonded to a carbon or silicon atom have no analogy in organic chemistry, therefore, considerable efforts will be devoted to studies of their activity. Also, synthesis and pharmacology of silylated derivatives of known medicinal . compounds will be investigated to establish correlations between the effect of the space-filling, lipophilic silyl groups and biological properties.