ADVANCING BIOMEDICAL RESEARCH & TRAINING IN PUERTO RICO

拟议的研究计划旨在调查目前的领域 生物医学的重要性，同时为波多黎各学生提供 有机会获得研究技能。 国际米兰董事会 波多黎各的美国大学支持计划的目标 研究和少数民族生物医学研究支持计划的目标。 研究者准备履行其研究承诺，并满足 MBRS的目标 拟开展的项目有：1）立体选择性制氧和制氮路线 具有生物医学潜力的螺环。 该项目旨在 潜在新抗生素和抗病毒剂的立体选择性制备 使用的方法是由主要开发的物质 调查员 2)神经免疫调节膜片钳研究PI是 感兴趣的细胞和亚细胞机制参与 神经免疫调节 膜片钳方法将用于监测离子 小鼠脾T淋巴细胞的通道活性及其受 神经传递素 3)市售海产及沿岸海产的弧菌种类 波多黎各的沃茨。 这项研究旨在检查市场上的食品 地方和河口沃茨在波多黎各的存在致病性 弧菌 4)肝片吸虫变种的特征。 在F.肝细胞物种可能是 显著 设计实验来确定遗传稳定性 和致病性。 5)空气中的致突变物是饮用水的污染物 水 将使用艾姆斯鼠伤寒沙门氏菌试验检测空气 饮用水中携带的诱变剂。 将通过以下方式识别突变体： 气相色谱-质谱-激光激发 荧光。 6)治疗血吸虫病的植物 杀软体动物剂。 这里的目标是检查一些药用植物， 抗曼氏血吸虫的治疗性质， 杀螺剂对蜗牛中间宿主的作用。 7)认知评价 老年人的西班牙裔人口。 人的认知评价 65至75年之间的时间将确定这些之间的差异， 生活在机构和家庭环境中的人。

The proposed research program is intended to investigate areas of current biomedical importance and at the same time provide Puerto Rican students with the opportunity to acquire research skills. The directorate of Inter American University of Puerto Rico supports the objectives of the planned research and the goals of the Minority Biomedical Research Support Program. Investigators are prepared to fulfill their research commitments and meet the MBRS goals. The proposed projects are: 1)Stereoselective Routes to Oxygen and Nitrogen Spirocycles with Biomedical Potential. This project is aimed at the stereoselective preparation of potentially new antibiotic and antiviral substances by the use of a methodology that was developed by the principal investigator. 2) Neuroimmunomodulation patch Clamp Studies PI is interested in the cellular and subcellular mechanisms involved in neuroimmunomodulation. Patch clamp methods will be used to monitor ion channel activity of murine spleen T lymphocytes and its modulation by neurotransmitter. 3) Vibrio Species in Market Level Seafood and Coastal Waters in Puerto Rico. This study is designed to examine foods in market places and estuarine waters in Puerto Rico for the presence of pathogenic vibrios. 4) Characterizing Variant Forms of Fasciola hepatica Species. Variations in the ovarian position observed in F. hepatica species could be significant. Experiments have been designed to determine genetic stability and pathogenicity. 5) Air Borne Mutagens as Contaminants of Drinking Water. The Ames Salmonella typhimurium assay will be used to detect air borne mutagens washed in drinking water. Mutagens will be identified by gas chromatography and mass spectrophotometry and laser-excited fluorescence. 6) Therapeutical Plants for Schistosomiasis and as Molluscicides. The goal here is to examine some medicinal plants for therapeutic properties against Schistosoma mansoni and which also serve as Molluscicides against the snail intermediate host. 7) Cognitive Evaluation of an Elderly Hispanic Populations. Cognitive evaluation of persons between 65 to 75 years will be made to determine differences between those living in institutions and those in their home environments.