ORGANOSILICON BIOMEDICAL RESEARCH

具体目的是研究其药理特性。 已知的活性有机分子的硅烷化衍生物和 鉴定不具有生物活性的有机硅化合物 知道碳的类比。 不含碳类似物的活性有机硅化合物似乎 为未来发现新的药物提供最大的潜力 化合物。含三个支链的有机硅化合物 或直接键合到碳或硅原子上的四个硅基 在有机化学中没有类似的东西，因此，相当可观 将致力于研究它们的活动。 此外，已知的硅烷化衍生物的合成和药理作用 药用的。将对化合物进行调查以确定 空隙填充效果与亲脂性的相关性 硅基和生物性质。

The specific aim is to investigate the Pharmacological properties of silylated derivatives of known active organic molecules and to identify biologically active organosilicon compounds that do not have known carbon analogy. Active organosilicon compounds without carbon analogy appears to offer the greatest potential for future discovery of new medicinal compounds. The branched-chain organosilicon compounds with three or four silyl groups directly bonded to a carbon or silicon atom have no analogy in organic chemistry, therefore, considerable efforts will be devoted to studies of their activity. Also, synthesis and pharmacology of silylated derivatives of known medicinal . compounds will be investigated to establish correlations between the effect of the space-filling, lipophilic silyl groups and biological properties.