ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER

需要资金购买一台EPR光谱仪，安装在 理工学院磁共振仪实验室 哈佛大学化学专业。我们寻求获得一台现代化的计算机- 一组用户可以通过大范围访问的驱动仪器 在电子顺磁共振波谱方面的专业知识，但尽管如此，仍是研究级的 能够完全满足用户群体需求的仪器。这个 所需的EPR仪器包括一台Bruker ESP系列光谱仪 配备了在X波段和Q波段工作所需的部件， 以及相关的用于样品操作的低温设备 温度从2K到环境温度。这台仪器将会是 用于推进一些生物学和生物科学的研究项目 生物医学兴趣：铁-硫团簇的生物无机化学 生物分子相互作用和界面的标记研究.生化 EDRF的研究及亚硝硫醇对血管和血小板的影响 功能；支持高场EPR和DNP实验的EPR研究；以及 Ras-p21蛋白结构的EPR研究。

Funds are requested to purchase an EPR spectrometer to be housed in the Magnetic Resonance Instrumentation Laboratory of the Department of Chemistry at Harvard University. We seek to acquire a modern, computer- driven instrument that is accessible to a group of users with a wide-range of expertise in EPR spectroscopy, but nonetheless a research-grade instrument capable of meeting the full needs of the users group. The requested EPR instrumentation includes a Bruker ESP-series spectrometer equipped with the necessary components for operation at X-band and Q-band, as well as the associated cryogenic equipment for operation at sample temperatures from 2 K to ambient temperature. This instrument will be utilized to advance a number of research projects of biological and biomedical interest: bioinorganic chemistry of iron-sulfur clusters; spin- label studies of biomolecular interactions and interfaces; biochemical studies of EDRF and the effects of nitrosothiols on vascular and platelet function; EPR studies in support of high-field EPR and DNP experiments; and EPR studies of the structure of ras-p21 proteins.