REQUEST FOR HIGH FIELD HORIZONTAL BORE NMR SPECTROMETER

这项赠款提案要求为水平钻孔提供部分资金支持， 高场大口径核磁共振波谱仪 主要用户群包括 确定了七个独立的研究项目，小组成员 在授予补助金时， 同行评审的NIH支持。 拟议预算的理由和使用 在研究计划的导言部分讨论了光谱仪 以及在个人研究项目中 描述。 该建议的主要力量来自个人研究 项目自己。 所有这些项目都取得了初步成果， 项目，以便可以认为所有项目都是可行的。 结果 一些项目将直接影响到临床 所有这些都将与生物医学相关。 的可用性 建议的光谱仪是必不可少的大多数项目，并将 显著提高所有项目实现其 研究目的。 该提案的另一个优势是通过以下途径提供专业知识： UCD NMR设备 一些主要用户组成员建议， 利用最先进的组织鉴别技术， 代谢物位置和分布的地形信息 他们的实验。 UCD核磁共振设施的工作人员参加了 开创性地利用这些技术在组织中，并积极 致力于扩展这些辨别实验的能力。 在UCD核磁共振设施开发的技术和方法将是 提供给主要用户组的所有成员。 拟议的核磁共振光谱仪将在UCD核磁共振的主持下 设施，以及增加拟定光谱仪的理由 载于提案中。

This grant proposal requests partial funding support for a horizontal bore, high field, wide bore NMR spectrometer. A Major User Group comprising seven separate research projects is identified, and members of the group either have, or expect to have at the time of the grant award, peer-reviewed NIH support. Justification and utilization of the proposed spectrometer are discussed in the introductory section of the Research Plan of the proposal, as well as within the individual research project descriptions. The major strength of the proposal comes from the individual research projects themselves. Preliminary results have been achieved on all of the projects, so that all may be considered to be proven feasible. The results of a number of the projects will have direct implications to clinical medicine, and all will have biomedical relevance. The availability of the proposed spectrometer is essential to a majority of the projects, and will markedly enhance the ability of all of the projects to achieve their research aims. An additional strength of the proposal is the expertise available through the UCD NMR Facility. A number of the Major User Group members propose to make use of state-of-the-art tissue discrimination techniques to obtan topographical information on metabolite locations and distributions in their experiments. UCD NMR Facility staff members have participated in pioneering utilization of these techniques in tissue, and are actively engaged in extending the capabilities of these discrimination experiments. The techniques and methodology developed at the UCD NMR Facility will be made available to all members of the Major User Group. The proposed NMR spectrometer will come under the auspices of the UCD NMR Facility, and justification for the addition of the proposed spectrometer is contained in the proposal.