ACQUISITION OF A 300 MHZ NMR SPECTROMETER

请求提供资金用于购买300兆赫核磁共振仪（QE-300，尼科莱） 光谱仪，以提高和扩大研究能力， 纽约化学系和生物系NIH获奖者 大学 仪器将在化学部存放和维护 在熟悉的实验室经理的监督下， 与尼科莱的技术。 对该仪器最迫切的需求是 威尔逊教授面临着少量的 天然存在的分子或其合成前体， 只有通过高场核磁共振才能理解结构。 强大需求 存在的仪器由其他教师与美国国立卫生研究院赠款或申请 它涵盖了广泛的健康相关项目，如DNA致癌物 相互作用，GAR转化酶的活性位点抑制剂， 胆囊收缩素拮抗剂、多巴胺类似物、组氨醇中的金属 脱氢酶和致癌物修饰的寡核苷酸。

Funds are requested for the purchase of a 300 MHz NMR (QE-300, Nicolet) spectrometer in order to improve and expand the research capabilities of NIH awardees in the Departments of Chemistry and Biology at New York University. The instrument will be housed and maintained in Chemistry Department space under the supervision of a Laboratory Manager familiar with Nicolet technologies. The most pressing need for the instrument is that of Professor Wilson who is confronted with small quantities of naturally occurring molecules or their synthetic precursors whose molecular architecture can only be understood with high-field NMR. Strong needs exist for the instrument by other faculty with NIH grants or applications that cover a broad range of health related projects such as DNA-carcinogen interactions, active-site inhibitors for GAR transformylase, cholecystokinin antagonists, dopamine analogues, metals in histidinol dehydrogenase and carcinogen-modified oligonucleotides.