DEC VAX 11/780 MOLECULAR MODELING SYSTEM

这项建议构成了一项努力，以获得计算和图形 支持现代生物分子结构所需的设施， Agouron研究所的分子生物学小组。 我们要求资金， 购买DEC VAX 11/780，配备适当的外围设备，包括打印机， 和新一代廉价磁盘和磁带驱动器，以及 交互式图形系统，如埃文斯和萨瑟兰彩色图片 系统330. 这一设施将使大量的现代计算工具可用 分子生物学和生物分子结构的科学家。 购置这种设备将发挥关键作用的项目 包括：基于结构蛋白质的位点特异性诱变; 肽激素和蛋白质的结构、力学和动力学， 基于结构的设计和合成tRNA分析物;基因结构， 下丘脑激素基因的调控和序列比较; 核糖核蛋白颗粒的结构和功能研究 转录。 目前，该中心没有计算机或交互式图形能力， Agouron和其他地方的计算机设施受到严格限制， 只有少数研究人员可以使用。

This proposal constitutes an effort to obtain computing and graphics facilities necessary for the support of a modern biomolecular structure and molecular biology group at the Agouron Institute. We request funds for the purchase of a DEC VAX 11/780 with adequate peripherals, including printer, plotter, and new generaton inexpensive disk and tape drives, as well as an interactive graphics system such as the Evans and Sutherland Color Picture System 330. This facility will make modern computing tools available to a large number of scientists involved in molecular biology and biomolecular structure. Projects for which acquisition of this equipment will play a pivotal role include: structurally based site specific mutagenesis of proteins; structure, mechanics and dynamics of peptide hormones and proteins, structurally based design and systhesis of tRNA analyogs; gene structure, regulation and sequence comparisons of hypothalamic hormone genes; structure and function studies of ribonucleoprotein particles involved in transcription. At present, there is no computer or interactive graphics capability at the Agouron, and computer facilities elsewhere are severely restricted and available to only a few researchers.