PURCHASE OF A NUCLEAR MAGNETIC RESONANCE SPECTROMETER

从共享的生物医学研究支持中申请资金 用于购买核磁共振的仪器计划 例如Magnacham A-200光谱仪(质子为200兆赫)。这 仪器将取代多核瓦里安XL-100仪器，后者具有 在过去的12年里一直是部门的主力核磁共振波谱仪。这个 XL-100在1970年是最先进的，但现在它不仅不能与 高场仪器的性能，但由于其年龄的原因，一些 更换部件正变得越来越难找到。尽管本质上是 低成本、延迟、技术人员查找部件的时间，以及由此产生的 仪器停机时间越来越长，阻碍了我们的研究。 新仪器在技术上比 XL-100，将允许在中等程度上快速测定光谱 常规高场，用户欢迎程度高 友善。该仪器将在日常工作中发挥重要作用。 十多个教员研究小组的研究计划 俄勒冈大学，其中许多目前是由美国国立卫生研究院拨款资助的。 直接受益于收购这一新的核磁共振的研究领域 光谱仪包括合成有机化学和机械有机化学 多种生物物理探针的设计、合成及应用 分子，酶反应机理的研究，以及对 模拟酶反应的机理。所有这些计划都涉及 新型有机分子的合成及核磁共振波谱分析 用于这些项目的新物质的表征方法。

Funds are requested from the Biomedical Research Support Shared Instrumentation Program for the purchase of a nuclear magnetic resonance spectrometer such as the Magnachem A-200 (200 MHz for protons). This instrument will replace a multinuclear Varian XL-100 instrument which has been the department workhorse NMR spectrometer over the past 12 years. The XL-100 was state-of-the-art in 1970, but now it not only does not match the performance of higher field instruments, but because of its age, some replacement parts are becoming difficult to locate. Although inherently inexpensive, the delays, technician time to locate parts, and resulting instrument down time are increasing to a level impeding our research. The new instrument constitutes a significant technical improvement over the XL-100 and will permit the rapid determination of spectra at moderately high field on a routine basis and with a welcome degree of user friendliness. The instrument will play an essential role in the day-to-day research programs of more than ten faculty research groups at the University of Oregon, many of whom are currently funded by NIH grants. Areas of research directly benefiting from acquisition of this new NMR spectrometer include synthetic and mechanistic organic chemistry, the design, synthesis and application of a variety of biophysical probe molecules, the study of enzyme reaction mechanisms, and the study of the mechanisms of model enzyme reactions. All of these programs involve the synthesis of new organic molecules and NMR spectral analysis is the chief method of characterization of new substances for these programs.