PHASE III TRIAL OF LOW FAT DIET

这项研究是应设计申请的要求而进行的 和第三阶段妇女低脂饮食试验的可行性评估 增加患乳腺癌的风险。我们的建议是设立一个 这项研究的临床单位。应用程序基于以下各项的可用性 一组乳腺癌高危女性通过 罗斯威尔公园纪念研究所的预防检测中心。这 人群，与其他从 乳房外科，由超过375人组成。 预防检测中心可接受性的事前评估 客户参与涉及饮食干预的研究 暗示有很高的兴趣。我们的研究计划将进一步确定 并确定可能参与饮食干预的个体的特征 减少乳腺癌的试验。我们的研究计划还检查了 通过定向干预可以实现的饮食变化 主要表现在减少膳食脂肪摄入量。我们的计划和设施 Describe将适合参与多机构试验。 将在《公约》可行性部分采用的研究方案 调查和长期研究将是以下方面的产物 与美国国家癌症研究所开展合作并制定方案 研究所工作人员。

This research is in response to a request for applications for the design and feasibility assessment of a Phase III Trial Low Fat Diet in Women at Increased Risk for Breast Cancer. Our proposal is for establishment of a clinical unit for this study. The application is based on availability of a cohort of women at high risk of breast cancer through the Prevention-Detection Center at Roswell Park Memorial Institute. This population, combined with other high risk patients identified from the Department of Breast Surgery, consists of in excess of 375 individuals. Prior assessments of the receptivity of Prevention-Detection Center clientele to participation in research involving dietary interventions suggest a high level of interest. Our research plan would further identify and characterize individuals likely to participate in dietary intervention trials to the reduction of breast cancer. Our research plan also examines the dietary changes that can be achieved through an intervention directed mainly at reduction of dietary fat intake. The program and facilities we describe will be suited for participation in a multi-institutional trial. The research protocol to be employed in the feasibility portion of the investigation and in the longer term study will be the product of collaboration and protocol development carried out with the National Cancer Institute staff.