COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS

绒毛膜绒毛活检，一种用于产前获得胎儿细胞的技术 目前正在积极调查中。 检测遗传 血管穿刺术的缺陷已经做出了重大贡献，医疗 遗传学，但绒毛活检可能提供产前检查， 诊断，以更大的妇女群体谁没有发现中期妊娠 程序可以接受。 利用率将迅速提高 绒毛活检，因此，研究的安全性和 这一程序的准确性是迫切需要的。 为了实现这一目标， 利用相同协议的多个中心的协作努力是 必需的. 一个模型协议是为病人登记，遗传咨询， 妊娠日期，宫颈培养，操作性能，样本 处理、数据收集和程序评估。 这将允许 建立（1）绒毛活检的准确性， 识别遗传异常胚胎/胎儿，以及（2） 诸如自然流产、低出生体重、早产 胎盘排斥、Rh同种免疫、胎儿畸形和新生儿 与绒毛取样有关的发育迟缓。

Chorionic villus biopsy, a technique for obtaining fetal cells for prenatal diagnosis, is now actively being investigated. Detection of genetic defects by amniocentesis has made significant contributions to medical genetics, but chorionic villus biopsy may offer access to prenatal diagnosis to a much larger group of women who do not find second trimester procedures acceptable. There will be a rapid increase in the utilization of chorionic villus biopsy and, therefore, a study of the safety and accuracy of this procedure is urgently needed. To accomplish this a collaborative effort of a number of centers utilizing the same protocol is required. A model protocol is presented for patient enrollment, genetic counseling, pregnancy dating, cervical culture, procedure performance, sample processing, data collection, and procedure assessment. This will allow establishment of (1) the accuracy of chorionic villus biopsy in identification of genetically abnormal embryos/fetuses, and (2) the rate of such complications as spontaneous abortions, low birth weight, prematurity placental abruption, Rh isoimmunization, fetal malformations, and neonatal developmental delay associated with chorionic villus sampling.